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C0620

CDK4/Cyclin D1, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinonimo/i:

BCL1, CMM3, D11S2878E, MG Cl4458, PRAD1, PSK-J3, U21 B31

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Taglio della confezioneSKUDisponibilitàPrezzo
10 μg
Per conoscere la disponibilità, visualizza il carrello
CHF 489.00

Informazioni su questo articolo

NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
12-16 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells

CHF 489.00

Per conoscere la disponibilità, visualizza il carrello
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recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

12-16 nmol/min·mg

mol wt

CDK4 subunit ~57 kDa, cyclin D1 ~61 kDa

UniProt accession no.

P11802, P24385

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CCND1(595), CDK4(1019)

Biochem/physiol Actions

CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of RB protein leading to an active transcriptional repression of E2F complex.CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

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Questo articolo
SRP0373C1249C1374
CDK4/Cyclin D1, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

C0620

CDK4/Cyclin D1, active, GST tagged human

CDK4/Cyclin D1 active human recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)

Sigma-Aldrich

SRP0373

CDK4/Cyclin D1 active human

CDK4/CyclinD3, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

C1249

CDK4/CyclinD3, active, GST tagged human

CDK6/CyclinD1, active, His/GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

C1374

CDK6/CyclinD1, active, His/GST tagged human

assay

≥70% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

specific activity

12-16 nmol/min·mg

specific activity

-

specific activity

13-19 nmol/min·mg

specific activity

7.9-10.7 nmol/min·mg

Gene Information

human ... CCND1(595), CDK4(1019)

Gene Information

human ... CCND1(595), CDK4(1019)

Gene Information

human ... CCND3(896), CDK4(1019)

Gene Information

human ... CCND1(595), CDK6(1021)

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

form

buffered aqueous glycerol solution

form

aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

UniProt accession no.

P11802, P24385

UniProt accession no.

-

UniProt accession no.

P11802, P30281

UniProt accession no.

P24385, Q00534

Classe di stoccaggio

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000480779
0000480779
SLBZ6890
SLBR8949V
SLBR4205V

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J W Harbour et al.
Cell, 98(6), 859-869 (1999-09-28)
We present evidence that phosphorylation of the C-terminal region of Rb by Cdk4/6 initiates successive intramolecular interactions between the C-terminal region and the central pocket. The initial interaction displaces histone deacetylase from the pocket, blocking active transcriptional repression by Rb.
Isao Matsuura et al.
Nature, 430(6996), 226-231 (2004-07-09)
Transforming growth factor-beta (TGF-beta) potently inhibits cell cycle progression at the G1 phase. Smad3 has a key function in mediating the TGF-beta growth-inhibitory response. Here we show that Smad3 is a major physiological substrate of the G1 cyclin-dependent kinases CDK4
S Mouron et al.
Nature communications, 13(1), 7529-7529 (2022-12-09)
Precision oncology research is challenging outside the contexts of oncogenic addiction and/or targeted therapies. We previously showed that phosphoproteomics is a powerful approach to reveal patient subsets of interest characterized by the activity of a few kinases where the underlying
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Numero articolo commerciale globale

SKUGTIN
C0620-10UG04061837753183

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