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B6684

Sigma-Aldrich

Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt

≥98% (HPLC), powder

Sinonimo/i:

Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3′,5′-cyclic monophosphorothioate sodium salt, Rp-8-Br-PET-cGMPS

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About This Item

Formula empirica (notazione di Hill):
C18H14BrN5NaO6PS
Numero CAS:
185246-32-6
Peso molecolare:
562.27
Codice UNSPSC:
41106305
ID PubChem:
24724424
NACRES:
NA.77

Saggio

≥98% (HPLC)

Stato

powder

Potenza

30 nM Ki

Colore

white to beige

Punto di fusione

240-300 °C (lit.)

Solubilità

H2O: 15 mg/mL at ≤60 °C

Temperatura di conservazione

−20°C

Stringa SMILE

O.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6

InChI

1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1
SVMPQLHYWRTQCX-DBHVCDLJSA-M

Azioni biochim/fisiol

Rp-8-Br-PET-cGMPS is a metabolically stable, competitive inhibitor of both PKG I (Ki = 30 nM) and PKG II. Blocks cGMP-gated retinal type ion channels (IC50 = 25 micromoles).
Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki = 30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50 = 25 micromoles).

Caratteristiche e vantaggi

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Note legali

U.S. Patent 5,625,056, DE Patent 4,217,679.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000089194
0000082250
0000016938
0000016216
125M4724V

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Sigma-Aldrich

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Sigma-Aldrich

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