Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

A9361

Sigma-Aldrich

Artemether

≥98% (HPLC)

Sinonimo/i:

Dihydroartemisinin methyl ether, Dihydroqinghaosu methyl ether, SM-224

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali

Scegli un formato

5 MG
CHF 81.80
25 MG
CHF 315.00

CHF 81.80

Check Cart for Availability
Richiedi un ordine bulk
Tutte le immagini(1)

Scegli un formato

Cambia visualizzazione
5 MG
CHF 81.80
25 MG
CHF 315.00

About This Item

Formula empirica (notazione di Hill):
C16H26O5
Numero CAS:
71963-77-4
Peso molecolare:
298.37
Numero MDL:
MFCD00866205
Codice UNSPSC:
51101908
ID PubChem:
329771050
NACRES:
NA.77

CHF 81.80

Check Cart for Availability
Richiedi un ordine bulk

Saggio

≥98% (HPLC)

Stato

powder

Attività ottica

[α]/D +155 to +175°, c = 0.5 in methanol

Colore

off-white to light brown

Solubilità

DMSO: ≥20 mg/mL

Ideatore

Novartis

Temperatura di conservazione

room temp

Stringa SMILE

CO[C@H]1OC2O[C@@]3(C)CCC4[C@H](C)CCC([C@H]1C)[C@@]24OO3

InChI

1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
SXYIRMFQILZOAM-HVNFFKDJSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Descrizione generale

Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant. [1]

Applicazioni

Artemether has been used:
  • as an anti-schistosomal compound to test it effect on the larval stages of S. mansoni[2]
  • to sensitize mouse embryonic fibroblasts (MEFs) and human osteosarcoma HT1080 cells to cysteine starvation (STV)-induced ferroptosis[1]
  • to stimulate islets and its effect on α to β transdifferentiation[3]

Azioni biochim/fisiol

Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.
Artemether is an anti-antimalarial compound.
Artemisinin possesses a highly reactive endoperoxide bridge, which is core for its therapeutic potential. The endoperoxide bond reacts with iron in the erythrocytes with malarial parasite. This leads to the generation of reactive oxygen species (ROS) directly targeting the parasite. Artemisinin also regulates ferroptosis in tumor cells.[1] The α cell transcription factor Arx expression is reduced by artemether. Prolonged exposure of primary islets also resulted in loss if identity in endocrine cell types and their functionality.[3]

Caratteristiche e vantaggi

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

FlameExclamation mark
GHS02,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H242,H302

Classi di pericolo

Acute Tox. 4 Oral - Org. Perox. D

Codice della classe di stoccaggio

5.2 - Organic peroxides and self-reacting hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
124M4701V
041M4712V
080M4701

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 10

1 of 10

USP

USP

1200520

Dihydroartemisinin

Artemisinin analytical standard

Supelco

69532

Artemisinin

Artemisinin United States Pharmacopeia (USP) Reference Standard

USP

1042747

Artemisinin

Piperaquine tetraphosphate tetrahydrate ≥98% (HPLC)

Sigma-Aldrich

C7874

Piperaquine tetraphosphate tetrahydrate

Atovaquone ≥98% (HPLC)

Sigma-Aldrich

A7986

Atovaquone

Primaquine bisphosphate 98%

Sigma-Aldrich

160393

Primaquine bisphosphate

Mefloquine hydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

M2319

Mefloquine hydrochloride

Amoxicillin 95.0-102.0% anhydrous basis

Sigma-Aldrich

A8523

Amoxicillin

Acetaminofene European Pharmacopoeia (EP) Reference Standard

P0300000

Acetaminofene

Chloroquine diphosphate salt powder or crystals, 98.5-101.0% (EP)

Sigma-Aldrich

C6628

Chloroquine diphosphate salt

Cong L Yuan et al.
Emerging infectious diseases, 18(1), 125-127 (2012-01-21)
The phylum Apicomplexa comprises intracellular protozoa that include many human pathogens. Their nearest relatives are chromerids and colpodellids. We report a case of a Babesia spp.-like relapsing infection caused by a newly described microorganism related to the Apicomplexa. This case
S H Xiao et al.
Parasitology today (Personal ed.), 16(3), 122-126 (2000-02-26)
The fight against schistosomiasis in China has been very effective in reducing the number of infections across the country. However, the drug of choice, praziquantel, has no prophylactic effect, which reduces its efficacy in high transmission areas. This situation has
Abel Nhama et al.
Malaria journal, 13, 309-309 (2014-08-12)
Mozambique adopted artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria in the year 2006, and since 2009 artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) have been proposed as alternative first-line treatments. A multicentre study was conducted in five
Dominic Mosha et al.
Antimicrobial agents and chemotherapy, 58(8), 4583-4592 (2014-05-29)
Artemether-lumefantrine (AL) is the first-line treatment for uncomplicated malaria in the second and third trimesters of pregnancy. Its efficacy during pregnancy has recently been challenged due to altered pharmacokinetic (PK) properties in this vulnerable group. The aim of this study
J Utzinger et al.
Current medicinal chemistry, 8(15), 1841-1860 (2002-01-05)
Human schistosomiasis, a chronic and debilitating parasitic disease of the tropics, is ranked second after malaria in terms of public health importance. At present, there is no vaccine available, and chemotherapy is the cornerstone of schistosomiasis control. Praziquantel is the
Visualizza tutti i documenti correlati

Articoli

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Questions

Reviews

No rating value

Active Filters

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.