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A3785

Sigma-Aldrich

5-Aminolevulinic acid hydrochloride

≥98%, suitable for ligand binding assays

Sinonimo/i:

δ-Aminolevulinic acid hydrochloride, 5-Amino-4-oxopentanoic acid hydrochloride, 5-Aminolaevulinic acid hydrochloride, ALA

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500 MG
CHF 195.00
1 G
CHF 417.00
5 G
CHF 1’420.00

CHF 195.00

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Cambia visualizzazione
500 MG
CHF 195.00
1 G
CHF 417.00
5 G
CHF 1’420.00

About This Item

Formula condensata:
NH2CH2C(O)CH2CH2COOH · HCl
Numero CAS:
5451-09-2
Peso molecolare:
167.59
Beilstein:
3690651
Numero CE:
226-679-5
Numero MDL:
MFCD00012869
Codice UNSPSC:
12352209
ID PubChem:
24890811
NACRES:
NA.26

CHF 195.00

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Nome del prodotto

5-Aminolevulinic acid hydrochloride, ≥98%

Livello qualitativo

300

Saggio

≥98%

Stato

powder

tecniche

ligand binding assay: suitable

Punto di fusione

150 °C

Temperatura di conservazione

−20°C

Stringa SMILE

Cl[H].NCC(=O)CCC(O)=O

InChI

1S/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H
ZLHFONARZHCSET-UHFFFAOYSA-N

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Categorie correlate

Applicazioni

5-Aminolevulinic acid hydrochloride has been used to activate or inhibit heme biosynthesis in HeLa and K562 cell lines.[1] It has also been used in photodynamic therapy for A431 tumor bearing mice.[2]

Azioni biochim/fisiol

5-Aminolevulinic acid (5-ALA) is an intermediate in heme biosynthesis and is useful in cancer treatment. It is a non-protein amino acid. 5-ALA also has applications in the field of agriculture.[3] It is being studied as an inducing reagent for protoporphyrin IX (PPIX) dependent fluorescence diagnosis of metastatic lymph nodes. 5-ALA is used for photodynamic therapy of diseases,[3] such as Paget′s disease and HPV infection-associated cervical condylomata acuminata.[4]
Intermediate in heme biosynthesis.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000325045
0000369398
0000369399
0000369400
0000364071

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USP

USP

1025726

Aminolevulinic acid Related Compound A

USP

USP

1025737

Aminolevulinic acid Related Compound B

4,6-Dioxoheptanoic acid powder

Sigma-Aldrich

D1415

4,6-Dioxoheptanoic acid

Protoporphyrin IX ≥95%

Sigma-Aldrich

P8293

Protoporphyrin IX

Temoporfin ≥90% (HPLC)

Sigma-Aldrich

SML1707

Temoporfin

Shigeru Kato et al.
The Journal of surgical research, 176(2), 430-436 (2012-01-10)
Lymph node metastasis is one of the most critical prognostic factors in patients with colorectal cancer. Although regional lymph nodes should be surgically resected and pathologically examined, techniques for the intraoperative diagnosis of lymph node metastasis remain to be well
Carla S Santos et al.
Plants (Basel, Switzerland), 8(9) (2019-09-22)
Iron deficiency chlorosis (IDC) is an abiotic stress often experienced by soybean, owing to the low solubility of iron in alkaline soils. Here, soybean lines with contrasting Fe efficiencies were analyzed to test the hypothesis that the Fe efficiency trait
Breann L Brown et al.
Structure (London, England : 1993), 26(4), 580-589 (2018-03-20)
5-Aminolevulinic acid synthase (ALAS) catalyzes the first step in heme biosynthesis. We present the crystal structure of a eukaryotic ALAS from Saccharomyces cerevisiae. In this homodimeric structure, one ALAS subunit contains covalently bound cofactor, pyridoxal 5'-phosphate (PLP), whereas the second
Treatment of HPV infection-associated cervical condylomata acuminata with 5-aminolevulinic acid-mediated photodynamic therapy.
Wang HW
Photochemistry and Photobiology, 88(3), 565-569 (2012)
ALA-PpIX variability quantitatively imaged in A431
epidermoid tumors using in vivo ultrasoundfluorescence
tomography and ex vivo assay
Alisha V DSouza
SPIE Proc., 8931 null
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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