A3145

Apigenin

≥97% (TLC), from parsley, powder

• Sinonimo/i: 4′,5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
• Formula empirica (notazione di Hill): C₁₅H₁₀O₅
• Numero CAS: 520-36-5
• Peso molecolare: 270.24
• Beilstein: 262620
• Numero CE: 208-292-3
• Numero MDL: MFCD00006831
• Codice UNSPSC: 12352200
• ID PubChem: 24278212

Proprietà

• Origine biologica: parsley
• Saggio: ≥97% (TLC)
• Stato: powder
• Colore: yellow
• Punto di fusione: >300 °C (lit.)
• Solubilità: DMSO: 27 mg/mL; 1 M KOH: 50 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H; KZNIFHPLKGYRTM-UHFFFAOYSA-N
• Informazioni sul gene: human ... ADORA3(140) , CDC2(983) , CDK5(1020) , CDK6(1021) , CYP1A2(1544) , ESR1(2099) , ESR2(2100) , GSK3A(2931) ; mouse ... Hexa(15211) ; rat ... Adora1(29290) , Adora2a(25369) , Il4(287287) , Tnf(24835)

Descrizione

Azioni biochim/fisiol

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibitory effects on tumor promotion may also be due to inhibition of kinase activity and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I catalyzed DNA religation and enhance gap junctional intercellular communication.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves