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Documenti fondamentali

A2221

Sigma-Aldrich

Antithrombin III from human plasma

lyophilized powder, ≥95% (SDS-PAGE)

Sinonimo/i:

Factor Xa inhibitor, Heparin cofactor

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About This Item

Numero CAS:
90170-80-2
Numero CE:
290-516-4
Numero MDL:
MFCD00166632
Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human plasma

Livello qualitativo

200

Saggio

≥95% (SDS-PAGE)

Stato

lyophilized powder

N° accesso UniProt

P01008

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... SERPINC1(462)

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Azioni biochim/fisiol

Serine protease inhibitor; Inhibitor of thrombin and activated factor X (Xa). Effective concentration equimolar with proteinase.

Linkage

Not to be confused with thrombin antiserum.

Definizione di unità

One unit will form a complex and inhibit one unit of bovine thrombin at 25 degree C, using a 5 minute incubation in the presence of heparin.

Stato fisico

Lyophilized from 20 mM Tris, pH 8.0

Esclusione di responsabilità

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000416602
0000416602
0000408077
0000406268
0000399995

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Coagulation Factor Xa, Human Plasma Coagulation Factor Xa, Human Plasma, CAS 9002-05-5, is a native coagulation factor Xa prepared from Factor X by activation with Russel′s viper venom. The venom is removed after activation.

Sigma-Aldrich

233526

Coagulation Factor Xa, Human Plasma

Alejandro Gugliucci
Life sciences, 82(7-8), 413-418 (2008-01-22)
Conditions in which serum or tissue acrolein levels are high (e.g.: renal failure, heavy smoking, oxidative stress) are also associated with increased thrombogenicity. Another emerging cardiovascular risk factor is homocysteine, and its derivative, homocysteine thiolactone. Antithrombin is one of the
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Biomedical materials (Bristol, England), 12(6), 065004-065004 (2017-10-06)
Biodegradable polymers have potential as a scaffold material for making small diameter artery bypass grafts. To resist thrombosis, maintain biocompatibility and enhance the remodeling of the grafts, it is crucial to modify polymer scaffolds so that the grafts have antithrombogenic
Xiaopeng Tang et al.
Cell research, 30(2), 119-132 (2019-12-08)
Coagulation balance is maintained through fine-tuned interactions among clotting factors, whose physiological concentrations vary substantially. In particular, the concentrations of coagulation proteases (pM to nM) are much lower than their natural inactivator antithrombin (AT, ~ 3 μM), suggesting the existence of other coordinators.
Hao Zhang et al.
Frontiers in cellular and infection microbiology, 11, 677902-677902 (2021-08-03)
Patients with sepsis may progress to acute respiratory distress syndrome (ARDS). Evidence of neutrophil extracellular traps (NETs) in sepsis-induced lung injury has been reported. However, the role of circulating NETs in the progression and thrombotic tendency of sepsis-induced lung injury

Protocolli

Thrombin from Bovine Plasma

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

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