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A2169

Sigma-Aldrich

3′-Azido-3′-deoxythymidine

≥98% (HPLC), powder, reverse transcriptase inhibitor

Sinonimo/i:

AZT, Azidothymidine, ZDV, Zidovudine

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25 MG
CHF 138.00
100 MG
CHF 270.00
250 MG
CHF 496.00
1 G
CHF 1’580.00

CHF 138.00

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Cambia visualizzazione
25 MG
CHF 138.00
100 MG
CHF 270.00
250 MG
CHF 496.00
1 G
CHF 1’580.00

About This Item

Formula empirica (notazione di Hill):
C10H13N5O4
Numero CAS:
30516-87-1
Peso molecolare:
267.24
Beilstein:
3595791
Numero MDL:
MFCD00006536
Codice UNSPSC:
12352200
ID PubChem:
24278143
NACRES:
NA.77

CHF 138.00

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Nome del prodotto

3′-Azido-3′-deoxythymidine, ≥98% (HPLC)

Saggio

≥98% (HPLC)

Stato

powder

Punto di fusione

113-115 °C (lit.)

Solubilità

H2O: 50 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
HBOMLICNUCNMMY-XLPZGREQSA-N

Informazioni sul gene

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

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Applicazioni

3′-Azido-3′-deoxythymidine has been used as the reverse transcriptase inhibitor to inhibit the viral genome integration[1] and as an antimicrobial agent to evaluate its anti-Salmonella activity.[2]

Azioni biochim/fisiol

Azidothymidine (AZT), a thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1 virus. Azidothymidine has been shown to decrease CRISPR-mediated homology-directed repair (HDR) efficiency.
Reverse transcriptase inhibitor active against HIV-1 virus.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pittogrammi

Health hazard
GHS08

Avvertenze

Warning

Indicazioni di pericolo

H341,H351

Classi di pericolo

Carc. 2 - Muta. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
MKCW0371
MKCW5948
MKCS1355
MKCR8766
MKCQ4508

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Modulation of homology-directed repair (HDR) within the context of CRISPR-genome editing has led to the identification of small molecules that enhance CRISPR-mediated HDR efficiency in various cell types.

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Questions

  1. For the use of this product in cell culture, what would be the best conditions for making stock solutions. Solvent, concentration, filtering, storage temp etc.?

    1 answer

    1. Unfortunately, this product has not been tested for cell culture applications. This compound is soluble at 50 mg/mL in water. For use in cell culture, the stock solution should be filter sterilized. Syringe filter product SLGVR33RS may be of interest. The pharmaceutical literature suggests that the stock solution is stable for 1 day at room temperature and 2 days if refrigerated.

      See the link below to a publication (page 3) regarding the stability of AZT in solution:
      https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019910s041lbl.pdf

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