A211050

DMT-2′O-TBDMS-rA(bz) Phosphoramidite

configured for (ÄKTA^® and OligoPilot^®)

• Sinonimo/i: DMT-2’O-TBDMS-rA(bz) Amidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-adenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• Formula empirica (notazione di Hill): C₅₃H₆₆N₇O₈PSi
• Numero CAS: 104992-55-4
• Peso molecolare: 988.19
• Numero MDL: MFCD00080297
• Codice UNSPSC: 12352200
• ID PubChem: 329770736
• NACRES: NA.51

Proprietà

• Origine biologica: non-animal source (no BSE/TSE risk)
• Livello qualitativo: 300
• Nome Commerciale: Proligo Reagents
• Saggio: ≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
• Stato: powder
• tecniche: oligo synthesis: suitable
• Impurezze: ≤0.3% water content (Karl Fischer); ≤0.5% P(III) Impurities 100-169ppm (³¹P-NMR); ≤0.5% single Impurity (reversed phase HPLC); ≤3% residual Solvent content
• Colore: white to off-white
• λ: conforms (UV/VIS Identity)
• Compatibilità: conforms to structure for H-NMR; conforms to structure for LC-MS; configured for (ÄKTA^® and OligoPilot^®)
• Profilo del nucleoside: base: adenosine; base protecting group: benzoyl; 2' protecting group: TBDMS; 5' protecting group: DMT; deprotection: standard
• Temperatura di conservazione: −20°C
• Stringa SMILE: COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
• InChI: 1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1; FFXHNCNNHASXCT-RFMFGJHUSA-N

Descrizione

Descrizione generale

RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques. Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides. High-quality RNA phosphoramidites are key to low failure rates, the high biological activity of synthesis products, and cost-effectiveness.

Key Features

• Industry-standard 2′O-TBDMS protective group
• Consistent lot-to-lot purity and performance
• Compatible with deprotection methods based on methylamine or AMA
• Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are obtained with activator 42
• Capping with standard acetic anhydride capping reagent rather than with fast Deprotection Cap A
• Manufactured under a certified ISO 9001 quality system

DMT-2′O-TBDMS-rA(bz) Phosphoramidite is configured for ÄKTA and OligoPilot Synthesizers.

Note legali

OligoPilot is a registered trademark of Cytiva

ÄKTA is a registered trademark of Cytiva

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable