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A0606

Sigma-Aldrich

Aurothioglucose hydrate

≥96% (titration)

Sinonimo/i:

Gold thioglucose, Solganal, Solganol

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About This Item

Formula empirica (notazione di Hill):
C6H11AuO5S · xH2O
Numero CAS:
12192-57-3
Peso molecolare:
392.18 (anhydrous basis)
Numero CE:
235-365-7
Codice UNSPSC:
12352200
ID PubChem:
24724383
NACRES:
NA.77

Saggio

≥96% (titration)

Forma fisica

powder

Condizioni di stoccaggio

desiccated

Colore

white to beige

Solubilità

H2O: 5 mg/mL, clear

Temperatura di conservazione

2-8°C

Stringa SMILE

O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1
SGVIEHTYEMEDRR-PKXGBZFFSA-M

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Applicazioni

Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.

Azioni biochim/fisiol

Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

Caratteristiche e vantaggi

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H317,H334

Classi di pericolo

Resp. Sens. 1 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Aurintricarboxylic acid practical grade, ≥85% (titration), powder

Sigma-Aldrich

A1895

Aurintricarboxylic acid

Cloruro d’oro(III) 99.995% trace metals basis

Sigma-Aldrich

254169

Cloruro d′oro(III)

cloruro di Oro(III) ACS reagent, ≥49.0% Au basis

Sigma-Aldrich

G4022

cloruro di Oro(III)

Agar for molecular biology

Sigma-Aldrich

A5306

Agar

Development of chrysiasis after Q-switched ruby laser treatment of solar lentigines.
David E Geist et al.
Journal of the American Academy of Dermatology, 55(2 Suppl), S59-S60 (2006-07-18)
Morgan L Locy et al.
Antioxidants & redox signaling, 17(10), 1407-1416 (2012-05-23)
Pulmonary oxygen toxicity contributes to lung injury in newborn and adult humans. We previously reported that thioredoxin reductase (TrxR1) inhibition with aurothioglucose (ATG) attenuates hyperoxic lung injury in adult mice. The present studies tested the hypothesis that TrxR1 inhibition protects
Yukiko Miyamoto et al.
Journal of medicinal chemistry, 64(10), 6608-6620 (2021-05-12)
Trichomonas vaginalis causes the most common, nonviral sexually transmitted infection. Only metronidazole (Mz) and tinidazole are approved for treating trichomoniasis, yet resistance is a clinical problem. The gold(I) complex, auranofin, is active against T. vaginalis and other protozoa but has
M D Levin et al.
The Netherlands journal of medicine, 61(6), 223-225 (2003-09-19)
Thrombocytopenia is a well-known side effect following intramuscular gold therapy in patients with rheumatoid arthritis. Thrombocytopenia may occur at any time and it can be irreversible and sometimes fatal despite cytotoxic or immunosuppressive therapy. We describe two patients who presented
Gabriela Maggioli et al.
The Journal of parasitology, 90(2), 205-211 (2004-05-29)
Thioredoxin reductase (TrxR), an enzyme belonging to the flavoprotein family of pyridine nucleotide-disulfide oxidoreductases, was isolated from the deoxycholate-soluble extract of the common liver fluke, Fasciola hepatica. Purification to homogeneity of the 60-kDa enzyme from the adult worm was achieved
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