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87128

Sigma-Aldrich

Tetracycline

98.0-102.0% (HPLC)

Sinonimo/i:

Tetracycline HCL, Tetracycline Monohydrochloride

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25 G
CHF 101.00
100 G
CHF 348.00

CHF 101.00

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Cambia visualizzazione
25 G
CHF 101.00
100 G
CHF 348.00

About This Item

Formula empirica (notazione di Hill):
C22H24N2O8 · xH2O
Numero CAS:
60-54-8
Peso molecolare:
444.43 (anhydrous basis)
Beilstein:
2230417
Numero CE:
200-481-9
Numero MDL:
MFCD00151232
Codice UNSPSC:
51284017
ID PubChem:
57653229
NACRES:
NA.85

CHF 101.00

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Origine biologica

synthetic

Saggio

98.0-102.0% (HPLC)

Stato

powder or crystals

Colore

faint yellow to dark yellow

Punto di fusione

172-174 °C (dec.)

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria

Modalità d’azione

protein synthesis | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
OFVLGDICTFRJMM-WESIUVDSSA-N

Informazioni sul gene

human ... CYP1A2(1544) , TERT(7015)

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Categorie correlate

Descrizione generale

Chemical structure: tetracycline

Azioni biochim/fisiol

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Confezionamento

25g, 100g

Altre note

Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place.

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08168

Timestrip Plus™ 8 °C

Avvertenze

Warning

Indicazioni di pericolo

H302,H361fd,H411

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000395313
0000384412
0000384412
0000395313
0000223580

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Supelco

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Sigma-Aldrich

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Sigma-Aldrich

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Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How to prepare stock solutions for item 87128-25G, Tetracycline?

    1 answer

    1. Tetracycline is soluble in methanol, giving a clear solution at up to 30 mg/ml. It is practically insoluble in chloroform and ether, very slightly soluble in water, slightly soluble in alcohol, very soluble in dilute hydrochloric acid and alkali hydroxide solutions.

      Helpful?

  4. devo fare lo stock della tetraciclina. come e in cosa la devo diluire?

    1 answer

    1. This product is soluble in methanol or ethanol, giving a completely clear solution at up to 30 mg/ml. The stability of this material in solution is pH-dependent. Stock solutions prepared in ethanol are estimated to be stable for 1-3 months when aliquoted and stored at -20°C. Please see the link below to review the product datasheet for T3258, an identical tetracycline product of another brand. The information provided applies to both products.
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/406/734/t3258dat.pdf

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