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336R-9

Sigma-Aldrich

Synaptophysin (MRQ-40) Rabbit Monoclonal Antibody

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100
500

Coniugato

unconjugated

Forma dell’anticorpo

culture supernatant

Tipo di anticorpo

primary antibodies

Clone

MRQ-40, monoclonal

Descrizione

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Confezionamento

vial of 0.1 mL concentrate (336R-94)
vial of 0.5 mL concentrate (336R-95)
bottle of 1.0 mL predilute (336R-97)
vial of 1.0 mL concentrate (336R-96)
bottle of 7.0 mL predilute (336R-98)

Produttore/marchio commerciale

Cell Marque™

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotipo

IgG1

Controllo

pancreas

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Visualizzazione

cytoplasmic

Informazioni sul gene

human ... SYP(6855)

Categorie correlate

Descrizione generale

Anti-synaptophysin reacts with neuroendocrine cells of the human adrenal medulla, pituitary,thyroid, lung, pancreas, and gastrointestinal mucosa. Positive staining is seen in neuronsof the brain. This antibody identifies normal neuroendocrine cells and neuroendocrineneoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probablycorrelates with the distribution of the antigen within neurosecretory vesicles. Antisynaptophysin is an independent, broad-range marker of neural and neuroendocrinedifferentiation.

Qualità


IVD
IVD
IVD
RUO

Linkage

Synaptophysin Positive Control Slides , Product No. 336S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificati d'analisi (COA)

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M Skacel et al.
Applied immunohistochemistry & molecular morphology : AIMM, 8(3), 203-209 (2000-09-12)
Histologic differential diagnosis of acinar cell carcinoma (ACC), mixed acinar-endocrine cell carcinoma (MAEC), and pancreatic endocrine tumors (PET) can be difficult but is important because of differences in their clinical behavior. This study investigates the utility of immunohistochemistry (IHC) in
Eun-Ik Son et al.
Pathology international, 53(2), 67-73 (2003-02-18)
Medulloblastomas occurring in children represent a histological spectrum of varying anaplasia and nodularity. In order to determine whether immunohistochemical markers might be useful parameters in subclassifying these tumors, 17 pediatric medulloblastomas, including nine diffuse/non-anaplastic, four diffuse/anaplastic, three nodular/non-anaplastic and one
Yasutaka Yamada et al.
Science translational medicine, 15(722), eadf6732-eadf6732 (2023-11-15)
Aberrant DNA methylation has been implicated as a key driver of prostate cancer lineage plasticity and histologic transformation to neuroendocrine prostate cancer (NEPC). DNA methyltransferases (DNMTs) are highly expressed, and global DNA methylation is dysregulated in NEPC. We identified that
M H Lyda et al.
Human pathology, 31(8), 980-987 (2000-09-15)
The histologic classification of pulmonary neoplasms can have important implications regarding appropriate management of patients. Although the histologic classification of lung tumors is predominantly based on morphology, ancillary studies such as immunohistochemistry can be used in difficult cases, and the
T Kamisawa et al.
Pathology, research and practice, 192(9), 901-908 (1996-09-01)
To evaluate the significance of neuroendocrine differentiation in duct carcinoma of the pancreas, we investigated 79 pancreatic carcinomas, applying histochemistry and immunohistochemistry (chromogranin A, Leu-7, synaptophysin and neuron-specific enolase (NSE), and correlated the morphologic differentiation pattern with clinicopathological characteristics. There
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