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Y0000016

Propofol

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

2,6-Diisopropylphenol, 2,6-Bis(1-methylethyl)phenol, 2,6-Bis(isopropyl)phenol, Propofol

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About This Item

Formula condensata:
[(CH3)2CH]2C6H3OH
Numero CAS:
2078-54-8
Peso molecolare:
178.27
Numero MDL:
MFCD00008885
Codice UNSPSC:
41116107
ID PubChem:
329830815
NACRES:
NA.24

Grado

pharmaceutical primary standard

Tensione di vapore

5.6 mmHg ( 100 °C)

Famiglia di API

propofol

Produttore/marchio commerciale

EDQM

Indice di rifrazione

n20/D 1.514 (lit.)

P. eboll.

256 °C/764 mmHg (lit.)

Punto di fusione

18 °C (lit.)

Densità

0.962 g/mL at 25 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)c1cccc(C(C)C)c1O

InChI

1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
OLBCVFGFOZPWHH-UHFFFAOYSA-N

Informazioni sul gene

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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Categorie correlate

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Propofol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

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1572525

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1572558

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PHR9049

4-Hydroxy-3,5-bis(1-methylethyl)benzoic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9062

1-(1-Methylethoxy)-2-(1-methylethyl)benzene, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR9074

2,2-Dimethyl-4-(1-methylethyl)-1,3-benzodioxole, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2565

Propofol Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2566

Propofol Related Compound B

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

235.4 °F - closed cup

Punto d’infiammabilità (°C)

113 °C - closed cup

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Certificati d'analisi (COA)

Lot/Batch Number

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Kim van Loon et al.
Anesthesia and analgesia, 119(1), 49-55 (2014-05-20)
Propofol, a short-acting hypnotic drug, is increasingly administered by a diverse group of specialists (e.g., cardiologists, gastroenterologists) during diagnostic and therapeutic procedures. Standard monitoring during sedation comprises continuous pulse oximetry with visual assessment of the patient's breathing pattern. Because undetected
Philippe E Dubois et al.
European journal of anaesthesiology, 31(8), 404-410 (2013-07-26)
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Shun-Chin Yang et al.
Journal of immunology (Baltimore, Md. : 1950), 190(12), 6511-6519 (2013-05-15)
Neutrophils play a critical role in acute and chronic inflammatory processes, including myocardial ischemia/reperfusion injury, sepsis, and adult respiratory distress syndrome. Binding of formyl peptide receptor 1 (FPR1) by N-formyl peptides can activate neutrophils and may represent a new therapeutic
Ryu Komatsu et al.
Anesthesia and analgesia, 117(6), 1329-1337 (2013-11-22)
Because etomidate impairs adrenal function and blunts the cortisol release associated with surgical stimulus, we hypothesized that patients induced with etomidate suffer greater mortality and morbidity than comparable patients induced with propofol. We evaluated the electronic records of 31,148 ASA
Marco M Sahinovic et al.
Anesthesia and analgesia, 119(2), 288-301 (2014-06-04)
The Composite Variability Index (CVI), derived from the electroencephalogram, was developed to assess the antinociception-nociception balance, whereas the Bispectral Index (BIS) was developed to assess the hypnotic state during anesthesia. We studied the relationships between these indices, level of hypnosis
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