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SMB01318

Sigma-Aldrich

3-Hydroxydesloratadine

Sinonimo/i:

3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity

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About This Item

Formula empirica (notazione di Hill):
C19H19ClN2O
Numero CAS:
119410-08-1
Peso molecolare:
326.82
Numero MDL:
MFCD00878381
NACRES:
NA.77

Descrizione

Modulation and Signaling

Livello qualitativo

100

Saggio

≥90%

Forma fisica

solid

tecniche

HPLC: suitable

Colore

pale yellow to off-white

Temperatura di conservazione

−20°C

InChI

1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
NDFMTPISBHBIKE-UHFFFAOYSA-N

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Descrizione generale

3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.

Applicazioni

3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research

Azioni biochim/fisiol

3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.

Caratteristiche e vantaggi

  • High quality compound suitable for multiple research applications
  • Compatible with a wide variety of chromatographic and spectrometry techniques

Altre note

For additional information on our range of Biochemicals, please complete this form.
This product is intended for research purposes only, and it is not meant for human consumption.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
MKCP4485

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Silvi A Chacko et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(6), 621-629 (2019-10-01)
Accurate prediction of in vivo metabolic pathways in humans can be challenging because in vitro liver matrices may fail to produce certain in vivo metabolites.Rat and human spheroids, generated from cryopreserved hepatocytes in media that contained minimal amount of serum
Matti K Itkonen et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(4), 377-385 (2019-01-12)
A recent in vitro study suggested that CYP2C8 is essential in the metabolism of desloratadine, an H1 receptor antagonist. If the proposed biotransformation mechanism takes place in vivo in humans, desloratadine could serve as a selective CYP2C8 probe substrate in
Faraz Kazmi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(4), 523-533 (2015-01-18)
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that is widely used for the treatment of allergic rhinitis and chronic idiopathic urticaria. For over 20 years, it has remained a mystery as to which

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