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PHR1304

Supelco

Butylated hydroxyanisole

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

2(3)-t-Butyl-4-hydroxyanisole, 2(3)-t-Butylhydroquinone monomethyl ether, BHA

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1 G
CHF 121.00

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CHF 121.00

About This Item

Formula condensata:
(CH3)3CC6H3(OCH3)OH
Numero CAS:
25013-16-5
Peso molecolare:
180.24
Numero CE:
246-563-8
Numero MDL:
MFCD01779059
Codice UNSPSC:
41116107
NACRES:
NA.24

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Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

300

agenzia

traceable to Ph. Eur. B1212000
traceable to USP 1083008

Densità del vapore

6.2 (vs air)

Famiglia di API

butylhydroxyanisole

CdA

current certificate can be downloaded

Temp. autoaccensione

599 °F

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

58-60 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-30°C

Stringa SMILE

O(C)c1cc(c(cc1)O)C(C)(C)C

InChI

1S/C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12/h5-7,12H,1-4H3
MRBKEAMVRSLQPH-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Applicazioni

Butylated hydroxyanisole (BHA) may be used as a reference standard for the determination of the analyte in pharmaceutical creams[1] by spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAB3751 in the slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Environment
GHS09

Indicazioni di pericolo

H411

Consigli di prudenza

P273 - P391 - P501

Classi di pericolo

Aquatic Chronic 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

241.9 °F - Pensky-Martens closed cup

Punto d’infiammabilità (°C)

116.6 °C - Pensky-Martens closed cup

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Certificati d'analisi (COA)

Lot/Batch Number

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3-tert-Butyl-4-hydroxyanisole United States Pharmacopeia (USP) Reference Standard

USP

1083100

3-tert-Butyl-4-hydroxyanisole

2,6-di-tert-butil-4-metilfenolo certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

75918

2,6-di-tert-butil-4-metilfenolo

tert-Butylhydroquinone analytical standard

Supelco

07293

tert-Butylhydroquinone

2,6-di-tert-butil-4-metilfenolo United States Pharmacopeia (USP) Reference Standard

USP

1082708

2,6-di-tert-butil-4-metilfenolo

2,6-di-tert-butil-4-metilfenolo European Pharmacopoeia (EP) Reference Standard

B1215000

2,6-di-tert-butil-4-metilfenolo

3-tert-Butyl-4-hydroxyanisole ≥98% (sum of isomers, GC), ≤10% 2-BHA basis (GC)

Sigma-Aldrich

20021

3-tert-Butyl-4-hydroxyanisole

Ethoxyquin PESTANAL®, analytical standard

Supelco

31519

Ethoxyquin

Simvastatin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1438

Simvastatin

Determination of miconazole in pharmaceutical creams using internal standard and second derivative spectrophotometry.
Wrobel K, et al.
Journal of Pharmaceutical and Biomedical Analysis, 20(1-2), 99-105 (1999)
In vivo studies on butylated hydroxyanisole.
F Iverson
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(9-10), 993-997 (1999-10-29)
H C Grice
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(8), 717-723 (1988-08-01)
Butylated hydroxyanisole (BHA) induces tumours of the squamous epithelium of the forestomach of rodents, but not at other sites. Although humans do not have squamous epithelium in their stomach the likelihood that BHA will induce tumours of the squamous epithelium
[Modification of the processes of chemical mutagenesis and carcinogenesis by synthetic phenol antioxidants such as butylated hydroxyanisole].
K Demkowicz-Dobrzański et al.
Postepy biochemii, 38(1), 37-42 (1992-01-01)
F Iverson
Cancer letters, 93(1), 49-54 (1995-06-29)
Synthetic phenolic antioxidants have been added to foods for decades to retard the autooxidation of lipid that leads to rancidity. The major antioxidants, butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), are used in foods world wide. Recent studies suggest that
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Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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