PHR1282

Azathioprine

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinonimo/i: 6-[(1-Methyl-4-nitro-1H imidazol-5yl) sulfanyl]-7H-purine, 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
• Formula empirica (notazione di Hill): C₉H₇N₇O₂S
• Numero CAS: 446-86-6
• Peso molecolare: 277.26
• Numero CE: 207-175-4
• Numero MDL: MFCD00069203
• Codice UNSPSC: 41116107
• ID PubChem: 329823278
• NACRES: NA.24

Proprietà

• Grado: certified reference material; pharmaceutical secondary standard
• Livello qualitativo: 300
• agenzia: traceable to BP 26; traceable to Ph. Eur. A1500000; traceable to USP 1046001
• Famiglia di API: azathioprine
• CdA: current certificate can be downloaded
• tecniche: HPLC: suitable; gas chromatography (GC): suitable
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Temperatura di conservazione: 2-30°C
• Stringa SMILE: Cn1cnc(c1Sc2ncnc3[nH]cnc23)[N+]([O-])=O
• InChI: 1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13); LMEKQMALGUDUQG-UHFFFAOYSA-N
• Informazioni sul gene: human ... PPAT(5471)

Descrizione

Descrizione generale

Azathioprine is a potentially useful antileukaemic drug,[1] with immunosuppressive action, which is administered orally or by I.V route. It is widely used to treat a variety of auto-immune disorders and also has a marked effect on T-lymphocytes and suppresses cell mediated immunity.[2]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Applicazioni

Azathioprine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[1][2] using ¹H NMR spectroscopy[1] and spectrophotometric techniques.[2]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAA0017 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H315,H319,H335,H350,H361fd
• Consigli di prudenza: P202 - P261 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3