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PHR1271

Supelco

Levodopa

Levodopa

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

3,4-Dihydroxy-L-phenylalanine, 3-(3,4-Dihydroxyphenyl)-L-alanine, L-3-Hydroxytyrosine, L-DOPA, Levodopa

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500 MG
CHF 123.00

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500 MG
CHF 123.00

About This Item

Formula condensata:
(HO)2C6H3CH2CH(NH2)CO2H
Numero CAS:
59-92-7
Peso molecolare:
197.19
Beilstein:
2215169
Numero CE:
200-445-2
Numero MDL:
MFCD00002598
Codice UNSPSC:
41116107
ID PubChem:
329823267
NACRES:
NA.24

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Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

300

agenzia

traceable to BP 213
traceable to Ph. Eur. L0400000
traceable to USP 1361009

Famiglia di API

levodopa

CdA

current certificate can be downloaded

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

276-278 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O

InChI

1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
WTDRDQBEARUVNC-LURJTMIESA-N

Informazioni sul gene

human ... DRD3(1814)

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Categorie correlate

Descrizione generale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Levodopa is a metabolic precursor of the neurotransmitter dopamine[1] and is widely used in the treatment of Parkinson′s disease.[2]

Applicazioni

Levodopa may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[3][4] using flow injection spectrophotometric method[3] and 1H nuclear magnetic resonance spectroscopy.[4]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAC2957 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Certificati d'analisi (COA)

Lot/Batch Number

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1 of 8

Benserazide hydrochloride European Pharmacopoeia (EP) Reference Standard

B0477000

Benserazide hydrochloride

Levodopa Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2095

Levodopa Related Compound A

Methyldopa United States Pharmacopeia (USP) Reference Standard

USP

1426002

Methyldopa

Carbidopa United States Pharmacopeia (USP) Reference Standard

USP

1095506

Carbidopa

Carbidopa British Pharmacopoeia (BP) Reference Standard

BP060

Carbidopa

S-(−)-Carbidopa ≥98% (TLC), powder

Sigma-Aldrich

C1335

S-(−)-Carbidopa

Benserazide hydrochloride British Pharmacopoeia (BP) Reference Standard

BP685

Benserazide hydrochloride

Tirosinasi lyophilized powder, ≥1000 unit/mg solid

Sigma-Aldrich

T3824

Tirosinasi

Parkinson's Disease and Related Disorders, 506(1), 97-104 (2006)
L H Marcolino-Júnior et al.
Journal of pharmaceutical and biomedical analysis, 25(3-4), 393-398 (2001-05-30)
A flow injection spectrophotometric procedure was developed for determining levodopa in tablets. The determination of this drug was carried out by reacting it with lead(IV) dioxide immobilized in polyester resin packed in a solid-phase reactor and the dopachrome yielded was
1H nuclear magnetic resonance spectroscopy analysis for simultaneous determination of levodopa, carbidopa and methyldopa in human serum and pharmaceutical formulations
Talebpour Z, et al.
Analytica Chimica Acta, 506(1), 97-104 (2004)
Handbook of Parkinson's Disease
Parkinson's Disease and Related Disorders, 506(4), 97-104 (2007)
A P de Jong et al.
Clinica chimica acta; international journal of clinical chemistry, 171(1), 49-61 (1988-01-15)
L-3-(3,4-Dihydroxyphenyl)alanine (DOPA) and its 3-O-methyl metabolite (OMD) were measured in plasma and cerebrospinal fluid by a new assay which combines N,O-acetylation of amino acids in aqueous media, preparation of pentafluorobenzyl esters under anhydrous conditions, and analysis by gas chromatography-electron capture
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Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. For how long should you store L-DOPA after elution?

    1 answer

    1. As a neat material stored at a refrigerated temperature and protected from light, levodopa is stable for at least 3 years. Levodopa is not stable in solution for long durations. According to peer-reviewed literature, levodopa degrades significantly in solution at ambient temperature over the course of 48 hours. The addition of a reducing agent such as ascorbate can prolong solution stability up to 72 hours. Refrigeration or freezing of the solution can significantly reduce levodopa degradation for up to 7 days. In general, it is recommended to prepare a solution of levodopa the day it is needed.

      Helpful?

  4. What is the best solvent that dissolves this product? To prepare the stock solution

    1 answer

    1. It is soluble in water (3 mg/ml), DMSO (<1 mg/ml at 25° C), and 0.5M HCl (50 mg/ml).

      Helpful?

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