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Documenti fondamentali

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M3157

Supelco

Minaprine dihydrochloride

analytical standard

Sinonimo/i:

N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine

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About This Item

Formula empirica (notazione di Hill):
C17H22N4O · 2HCl
Numero CAS:
25905-77-5
Peso molecolare:
371.30
Numero CE:
247-329-8
Numero MDL:
MFCD00083410
Codice UNSPSC:
41116107
ID PubChem:
329817964
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

200

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

Cl.Cl.Cc1cc(nnc1NCCN2CCOCC2)-c3ccccc3

InChI

1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H
GNUCGROXDZMCJI-UHFFFAOYSA-N

Informazioni sul gene

human ... ACHE(43) , CHRM1(1128) , DRD2(1813) , HTR2B(3357) , HTR2C(3358) , MAOA(4128) , SLC6A4(6532)
rat ... Ache(83817) , Camk2a(25400) , Prkca(24680)

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Azioni biochim/fisiol

Antidepressant

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number

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J G Edwards et al.
British journal of clinical pharmacology, 42(4), 491-498 (1996-10-01)
1. A double-blind, multicentre study comparing the efficacy and safety of minaprine and amitriptyline in patients with major depression was carried out. Five hundred and thirty-one patients were randomly assigned to treatment with either minaprine 100 mg, 200 mg or
S Cabib et al.
Psychopharmacology, 121(1), 73-80 (1995-09-01)
Different types of clinically effective antidepressants prevent the behavioral effects of experimental stress, and some of these treatments affect mesolimbic dopamine (DA) functioning. Animal studies have demonstrated that repeated psychostimulant administration and repeated or chronic stressful experiences also affect mesolimbic
Y Karasawa et al.
Physiology & behavior, 52(1), 141-147 (1992-07-01)
We attempted to determine if the cholinomimetic activity of the psychotropic drug minaprine was related to the amelioration of the delayed neuronal death induced by cerebral ischemia in Mongolian gerbils. Minaprine improved the passive avoidance deficit induced by cerebral ischemia
T R Norman et al.
The Australian and New Zealand journal of psychiatry, 26(1), 73-81 (1992-03-01)
A review of the clinical efficacy of four structurally distinct antidepressant drugs is presented. Their antidepressant activity can be rationalised within current pharmacological hypotheses of drug action, despite markedly different effects on "in vitro" testing. Fluoxetine, a specific serotonin re-uptake
C A Lorenzini et al.
Pharmacology, biochemistry, and behavior, 45(2), 481-485 (1993-06-01)
The nootropic activity of 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl-pyridazine dihydrochloride (minaprine) has been investigated in intact male, adult Long Evans rats by means of an active avoidance paradigm. In the light-dark box apparatus, the rat had to learn the active avoidance response of going
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