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C2162700

Ciclopirox olamine

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolammonium salt

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About This Item

Formula empirica (notazione di Hill):
C12H17NO2 · C2H7NO
Numero CAS:
41621-49-2
Peso molecolare:
268.35
Numero MDL:
MFCD00078997
Codice UNSPSC:
41116107
ID PubChem:
329774970
NACRES:
NA.24
Prezzi e disponibilità al momento non sono disponibili

Grado

pharmaceutical primary standard

Famiglia di API

ciclopirox

Produttore/marchio commerciale

EDQM

applicazioni

pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

NCCO.CC1=CC(=O)N(O)C(=C1)C2CCCCC2

InChI

1S/C12H17NO2.C2H7NO/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10;3-1-2-4/h7-8,10,15H,2-6H2,1H3;4H,1-3H2
MBRHNTMUYWQHMR-UHFFFAOYSA-N

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Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Ciclopirox olamine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

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Y0000040

Ciclopirox, European Pharmacopoeia (EP) Reference Standard

1134030

Ciclopirox olamine, United States Pharmacopeia (USP) Reference Standard

1134040

Ciclopirox Related Compound B, United States Pharmacopeia (USP) Reference Standard

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Ciclopirox, United States Pharmacopeia (USP) Reference Standard

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Ciclopirox Related Compound C, United States Pharmacopeia (USP) Reference Standard

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Ciclopirox Related Compound A, United States Pharmacopeia (USP) Reference Standard

PHR1920

Ciclopirox, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2854

Ciclopirox Related Compound B, certified reference material, pharmaceutical secondary standard

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Sigma-Aldrich

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Sigma-Aldrich

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D Monti et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 27(2), e153-e158 (2012-03-28)
In a previous study a new hydrosoluble nail lacquer (P-3051) containing 8% ciclopirox (CPX) showed higher nail penetration compared to a water-insoluble 5% amorolfine (MRF) lacquer. To our knowledge, in vivo human data on a similar topic are not available.
D Monti et al.
The British journal of dermatology, 165(1), 99-105 (2011-03-18)
Topical therapy has recently been proposed for treating onychomycosis and other nail disturbances. However, the clinical outcome may be limited by the difficulty of active ingredients effectively penetrating the nail plate. Bovine hoof membranes have been widely used to predict
Tsuyoshi Shimamura et al.
Antimicrobial agents and chemotherapy, 55(7), 3150-3155 (2011-05-11)
We developed a novel model of onychomycosis in which we observed fungi in the deep layer of the nail, and we used the model to evaluate the efficacy of two topical antifungal drugs. To establish an experimental, in vivo model
Young Kim et al.
In vivo (Athens, Greece), 25(6), 887-893 (2011-10-25)
Aberrant activation of Wnt/β-catenin signaling promotes the development of several types of cancer. Recently, it has been demonstrated that Wnt pathway is also activated in myeloma. Therefore, the Wnt/β-catenin signaling molecules are attractive candidates for development of targeted therapies for
S G Jue et al.
Drugs, 29(4), 330-341 (1985-04-01)
Ciclopirox olamine is a substituted pyridone antimycotic, unrelated to the imidazole derivatives, with activity against a broad spectrum of dermatophytes, yeasts, actinomycetes, molds, other fungi, and a variety of Gram-positive and Gram-negative bacteria. The efficacy of ciclopirox olamine cream has
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