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A36883

Sigma-Aldrich

Aurintricarboxylic acid ammonium salt

ACS reagent, powder or crystals

Sinonimo/i:

ATA, Aluminon, Ammonium aurintricarboxylate

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About This Item

Formula condensata:
C22H14O9 · 3NH3
Numero CAS:
569-58-4
Peso molecolare:
473.43
Colour Index:
43810
Beilstein:
3900820
Numero CE:
209-319-1
Numero MDL:
MFCD00040925
Codice UNSPSC:
12171500
ID PubChem:
24890803
NACRES:
NA.47

product name

Aurintricarboxylic acid ammonium salt, ACS reagent

Origine biologica

synthetic

Livello qualitativo

300

Grado

ACS reagent

Forma fisica

powder or crystals

Impurezze

≤0.1% insolubles

Residuo alla calcinazione

≤0.2%

Colore

dark red

Punto di fusione

220-225 °C (dec.) (lit.)

Solubilità

water: soluble 100 mg/mL

λmax

450 nm
522 nm (2nd)

applicazioni

diagnostic assay manufacturing
hematology
histology

Temperatura di conservazione

room temp

Stringa SMILE

N.N.N.OC(=O)c1cc(ccc1O)\C(c2ccc(O)c(c2)C(O)=O)=C3/C=CC(=O)C(=C3)C(O)=O

InChI

1S/C22H14O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31);3*1H3
AIPNSHNRCQOTRI-UHFFFAOYSA-N

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Categorie correlate

Applicazioni

Reagent for aluminum

Azioni biochim/fisiol

Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.

Altre note

May contain a substantial amount of polymeric material.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
SHBR7029
SHBS1038
SHBR0144
SHBQ2231
SHBL7702

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Hui-Chen Hung et al.
The Journal of antimicrobial chemotherapy, 65(4), 676-683 (2010-01-22)
Enterovirus 71 (EV71) causes serious diseases in humans. The aim of this study was to examine the effects of aurintricarboxylic acid (ATA) on EV71 replication and to explore the underlying mechanism. To measure the activity of ATA in inhibiting the
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Complement plays a vital role in both the innate and adaptive immune systems. It recognizes a target, opsonizes it, generates anaphylatoxins, and directly kills cells through the membrane attack complex (MAC). This final function, which assembles C5b-9(n) on viable cell
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