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Documenti fondamentali

67403

Supelco

Cirsilineol

analytical standard

Sinonimo/i:

4′,5-Dihydroxy-3′,6,7-trimethoxyflavone, 6-Methoxyluteolin 3′,7-dimethyl ether, Anisomelin, Eupatrin, Fastigenin

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About This Item

Formula empirica (notazione di Hill):
C18H16O7
Numero CAS:
Peso molecolare:
344.32
Beilstein:
1355108
Numero MDL:
Codice UNSPSC:
85151701
ID PubChem:
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

Saggio

≥95.0% (HPLC and enzymatic)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

food and beverages

Formato

neat

Stringa SMILE

COc1cc(ccc1O)C2=CC(=O)c3c(O)c(OC)c(OC)cc3O2

InChI

1S/C18H16O7/c1-22-13-6-9(4-5-10(13)19)12-7-11(20)16-14(25-12)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3
VKOSQMWSWLZQPA-UHFFFAOYSA-N

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Descrizione generale

Cirsilineol is a bioactive flavone isolated from the herb of Artemisia vestita Wall., widely used to treat a variety of inflammatory conditions such as contact dermatitis, rheumatoid arthritis and sepsis. Cirsilineol exhibits anti-proliferative activity, which is used against different cancer cells by inducing apoptosis.

Applicazioni

Cirsilineol may be used as an analytical reference standard for the quantification of the analyte in vervain samples and extracts of Teucrium polium using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

Lot/Batch Number

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HPLC and UV-spectrophotometry analysis of flavonoids in spray-dried and freez-dried extracts of Teucrium polium L.(Lamiaceae)
Stefkov G, et al.
Macedonian pharmaceutical bulletin, 47(11), 39-44 (2012)
[Flavones isolated from Thymus carnosus Boiss].
E Maruhenda et al.
Annales pharmaceutiques francaises, 45(6), 467-470 (1987-01-01)
Xia Sheng et al.
The Journal of pharmacy and pharmacology, 60(11), 1523-1529 (2008-10-30)
Cirsilineol (4',5-dihydroxy-3',6,7-trimethoxyflavone) is a compound isolated from the herb of Artemisia vestita Wall (Compositae). In this study, we aimed at examining the anti-proliferative activity of cirsilineol against multiple types of cancer cells and the underlying mechanisms. Cirsilineol significantly inhibited proliferation
Qi-wei Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 27(1), 23-25 (2003-05-31)
To establish a quantitative method for determination of cirsilineol in Herba Artemisiae Scopariae collected in Autumn. Sample was extracted with methanol, and cleaned up with polyamide column. ODS column was used with methanol-acetonitrile-0.5% acetic acid solution (24:19:57) as mobile phase.
H J Heo et al.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 8(3), 194-201 (2001-10-26)
Amyloid beta protein (Abeta)-induced free radical-mediated neurotoxicity is a leading hypothesis as a cause of Alzheimer's disease (AD). Abeta increased free radical production and lipid peroxidation in PC12 nerve cells, leading to apoptosis and cell death. The effect of 4',5-dihydroxy-3',6,7-trimethoxyflavone

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