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62484

Sigma-Aldrich

Lithium citrate tribasic tetrahydrate

BioUltra, ≥99.5% (NT)

Sinonimo/i:

Citric acid trilithium salt, Trilithium citrate tetrahydrate

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About This Item

Formula condensata:
HOC(COOLi)(CH2COOLi)2 · 4H2O
Numero CAS:
6080-58-6
Peso molecolare:
281.98
Numero CE:
213-045-8
Numero MDL:
MFCD00150030
Codice UNSPSC:
12161700
ID PubChem:
329759732
NACRES:
NA.25

Nome Commerciale

BioUltra

Livello qualitativo

200

Saggio

≥99.5% (NT)

Forma fisica

solid

Impurezze

insoluble matter, passes filter test

pH

8.0-9.5 (25 °C, 1 M in H2O)

Solubilità

H2O: 1 M at 20 °C, clear, colorless

Anioni in tracce

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

Cationi in tracce

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

Assorbanza UV

λ: 260 nm Amax: 0.040
λ: 280 nm Amax: 0.016

Stringa SMILE

[Li+].[Li+].[Li+].O.O.O.O.OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

1S/C6H8O7.3Li.4H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;4*1H2/q;3*+1;;;;/p-3
HXGWMCJZLNWEBC-UHFFFAOYSA-K

Informazioni sul gene

human ... GSK3A(2931) , GSK3B(2932) , IMPA1(3612)

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Categorie correlate

Applicazioni

Lithium citrate is useful as a potential therapeutic for Canavan disease due to aspartoacylase deficiency or aminoacylase 2 deficiency.

Altre note

Quantification of physiological amino acids by gradient lithium ion-exchange HPLC

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
BCCH1073
BCCK3425
BCCC9061
BCBZ4546
BCBV6100

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Treating PIK3CA and EGFR overexpressing breast cancers with lithium citrate.
Toni M Brand et al.
Cancer biology & therapy, 11(3), 368-370 (2011-01-14)
Christopher G Janson et al.
Pediatric neurology, 33(4), 235-243 (2005-10-01)
Current evidence suggests that the effects of lithium on metabolic and signaling pathways in the brain may vary depending on the specific clinical condition or disease model. For example, lithium increases levels of cerebral N-acetyl aspartate in patients with bipolar
S E Møller
Journal of chromatography, 613(2), 223-230 (1993-04-02)
A single-column gradient lithium ion-exchange chromatographic method with post-column derivatization and fluorimetric detection for the quantification of physiological amino acids is described. The method runs automatically, requires a minimum of sample preparation, separates all amino acids in plasma and cerebrospinal
Lithium citrate reduces excessive intra-cerebral N-acetyl aspartate in Canavan disease.
Assadi M, Janson C, Wang DJ, et al.
European Journal of Pediatrics, 14, 354-359 (2010)
María Dolores Edo Solsona et al.
Clinical neuropharmacology, 35(3), 150-151 (2012-05-18)
Canavan disease is a rare autosomal recessive leukodystrophy characterized by abnormal accumulation of N-acetyl aspartate (NAA) in brain white matter. Currently, there is no cure for this disease, and management of patients consists mainly of treating symptoms. We describe a

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