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Documenti

03738

Supelco

5-Fluorouracil

analytical standard

Sinonimo/i:

2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione

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About This Item

Formula empirica (notazione di Hill):
C4H3FN2O2
Numero CAS:
51-21-8
Peso molecolare:
130.08
Beilstein:
127172
Numero CE:
200-085-6
Numero MDL:
MFCD00006018
Codice UNSPSC:
41116107
ID PubChem:
329747789
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

100

Saggio

≥99.0% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Impurezze

≤0.5% water

Punto di fusione

282-286 °C (dec.) (lit.)

applicazioni

cleaning products
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

FC1=CNC(=O)NC1=O

InChI

1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
GHASVSINZRGABV-UHFFFAOYSA-N

Informazioni sul gene

human ... TYMS(7298)

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Categorie correlate

Descrizione generale

5-Fluorouracil is an anti-tumor agent, widely used in the treatment of various malignancies.

Applicazioni

5-Fluorouracil may be used as an analytical standard for the determination of the analyte in hospital effluents by capillary electrophoresis, and in biological samples and environmental samples by chromatography based techniques.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301,H351

Classi di pericolo

Acute Tox. 3 Oral - Carc. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Certificati d'analisi (COA)

Lot/Batch Number
BCCH5111
BCCJ2687
BCCF1011
BCCC1036
BCBW4726

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G Micoli et al.
Journal of chromatography. B, Biomedical sciences and applications, 750(1), 25-32 (2001-02-24)
5-Fluorouracil (5-FU) is one of the most widely used antineoplastic drugs. It can be therefore considered to be a model compound for the identification of exposure routes during preparation and administration of cytostatic agents, especially for nucleoside analogue drugs. In
Susanne N Mahnik et al.
Analytical and bioanalytical chemistry, 380(1), 31-35 (2004-09-15)
Cytostatic anticancer drugs are an increasingly important issue in the environmental debate, mainly due to the lack of knowledge about the fate of these toxic substances. Over the last decades, 5-fluorouracil (5-FU) has been one of the most frequently used
A sensitive method for determination of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in human plasma by high-pressure liquid chromatography.
A R Buckpitt et al.
Analytical biochemistry, 106(2), 432-437 (1980-08-01)
Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer
Carethers JM, et al.
Gastroenterology, 126(2), 394-401 (2004)
5-fluorouracil: mechanisms of action and clinical strategies
Longley DB, et al.
Nature Reviews. Cancer, 3(5), 330-338 (2003)
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