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02712

SAFC

Cystamine dihydrochloride

Produzione farmaceutica

Sinonimo/i:

2,2′-Diaminodiethyl disulfide dihydrochloride, 2,2′-Dithiobis(ethylamine) dihydrochloride, Decarboxycystine dihydrochloride

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About This Item

Formula condensata:
NH2CH2CH2SSCH2CH2NH2 · 2HCl
Numero CAS:
56-17-7
Peso molecolare:
225.20
Beilstein:
3616850
Numero CE:
200-260-7
Numero MDL:
MFCD00012905
Codice UNSPSC:
12352100
NACRES:
NA.21

Origine biologica

synthetic

Livello qualitativo

500

Saggio

≥98.0% (TLC)

Concentrazione

≥98 % (w/w) (T)

Impurezze

≤100 mg/kg 2,6-Di-tert-butyl-4-methylphenol (BHT) (HPLC)
≤100 ppm 1,2-dimethoxyethan
≤5000 ppm tert-butyl methyl ether
≤5000 ppm ethanol

Punto di fusione

215-225 °C (dec.)
217-220 °C (dec.) (lit.)

Solubilità

H2O: 1.0 g/10 mL, clear to almost clear, colorless to almost colorless (<5.5 NTU)

Compatibilità

corresponds for H-NMR

Stringa SMILE

Cl[H].Cl[H].NCCSSCCN

InChI

1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1H
YUFRRMZSSPQMOS-UHFFFAOYSA-N

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Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
BCCB2795
BCCB2794
BCBZ6822
BCBZ5212
BCBZ4055

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Sigma-Aldrich

M6500

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Cysteamine hydrochloride &#8805;97.0% (RT)

Sigma-Aldrich

30080

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Supelco

49705

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2-Mercaptoethylamine, polymer-bound 70-90&#160;mesh, extent of labeling: 0.6-1.1&#160;mmol/g loading, 1&#160;% cross-linked with divinylbenzene

Sigma-Aldrich

641022

2-Mercaptoethylamine, polymer-bound

Cysteamine ~95%

Sigma-Aldrich

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N,N&#8242;-Bis(acryloyl)cystamine BioReagent, suitable for electrophoresis

Supelco

A4929

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Shosuke Ito et al.
Biochemical pharmacology, 84(5), 646-653 (2012-06-26)
Metastatic melanoma is resistant to conventional therapies. N-propionyl-4-S-cysteaminylphenol (NPrCAP), an N-protected sulfur-amine analog of tyrosine, is a good substrate for tyrosinase and is selectively incorporated into melanoma cells, causing cytotoxicity in vitro and in vivo. We have recently shown that
Thorsten Overath et al.
Molecular & cellular proteomics : MCP, 11(8), 467-477 (2012-05-05)
The post-translational modification of proteins with O-GlcNAc is involved in various cellular processes including signal transduction, transcription, translation, and nuclear transport. This transient protein modification enables cells or tissues to adapt to nutrient conditions or stress. O-Glycosylation of the 26
Yasue Ishii-Osai et al.
Journal of dermatological science, 67(1), 51-60 (2012-05-25)
N-propionyl-4-S-cysteaminylphenol (NPr-4-S-CAP) is selectively incorporated into melanoma cells and degrades them. However, it remains unclear whether NPr-4-S-CAP can induce cell death associated with the induction of host immune responses and tumor suppression in vivo. To examine the molecular mechanism of
Liang Gao et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(11), 3185-3192 (2012-02-22)
Autofluorescent microcapsules were assembled by covalent cross-linking of polysaccharide alginate dialdehyde (ADA) derivative and cystamine dihydrochloride (CM) through a layer-by-layer (LBL) technique. The formulated Schiff base and disulfide bonds render capsules with pH- and redox-responsive properties for pinpointed intracellular delivery
Zhongshan Liu et al.
Journal of chromatography. A, 1342, 70-77 (2014-04-15)
A polyhedral oligomeric silsesquioxane (POSS) hybrid monolith was simply prepared by using octaglycidyldimethylsilyl POSS (POSS-epoxy) and cystamine dihydrochloride as monomers via ring-opening polymerization. The effects of composition of prepolymerization solution and polycondensation temperature on the morphology and permeability of monolithic
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