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Merck
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10295892001

Roche

Colcemid

solution, suitable for blocking, sterile; 0.2 μm filtered

Sinonimo/i:

Demecolcine, N-Deacetyl-N-methylcolchicine

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About This Item

Formula empirica (notazione di Hill):
C21H25NO5
Numero CAS:
477-30-5
Peso molecolare:
371.43
Beilstein:
2822892
Numero MDL:
MFCD00075459
Codice UNSPSC:
12352207
ID PubChem:
329749009

Descrizione

N-methyl-N-deacetyl-colchicine

Livello qualitativo

100

Sterilità

sterile; 0.2 μm filtered

Forma fisica

solution

Confezionamento

pkg of 20 mL (10 μg/ml)

Produttore/marchio commerciale

Roche

tecniche

blocking: suitable

Impurezze

microbial, tested

Solubilità

water: miscible

Temperatura di conservazione

2-8°C

Stringa SMILE

CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13

InChI

1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
NNJPGOLRFBJNIW-HNNXBMFYSA-N

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Categorie correlate

Descrizione generale

Colcemid is also known as demecolcine. Its generic name is N-methyl-N-deacetyl-colchicine. Colcemid depolymerizes microtubules and blocks mitosis at metaphase.

Applicazioni

Colcemid inhibits the formation of mitotic spindles. It is used to increase the percentage of metaphase cells for chromosome analysis.

Azioni biochim/fisiol

Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

Stato fisico

Solution (10 μg/ml), filtered through 0.2 μm pore size membrane.

Altre note

For life science research only. Not for use in diagnostic procedures.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

does not flash

Punto d’infiammabilità (°C)

does not flash

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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