MABN669
Anti-Dopamine Transporter Antibody, clone mAb16
clone mAB16, from mouse
Sinonimo/i:
Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3
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100 μG
CHF 438.00
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Cambia visualizzazione
100 μG
CHF 438.00
About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
mAB16, monoclonal
Reattività contro le specie
mouse, rat
tecniche
western blot: suitable
Isotipo
IgG1
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
mouse ... Slc6A3(13162)
rat ... Slc6A3(24898)
Descrizione generale
The transmembrane dopamine transporter (DAT) is located on the presynaptic nerve terminal and is responsible for terminating dopaminergic transmission by transporting dopamine from the synaptic cleft into the dopaminergic neuron (reuptake). Dopaminergic pathways have been strongly implicated in reward and addiction, motivation, alcoholism, ADHD and degenerative motor diseases such as Parkinson′s, Huntington′s and Chorea. EMD Millipore’s Anti-Dopamine Transporter antibody has been validated in western blotting for mouse and rat specimens.
Specificità
This antibody recognizes the cytoplasmic domain of Dopamine Transporter.
Immunogeno
Epitope: Cytoplasmic domain
Linear peptide corresponding to the cytoplasmic domain of rat Dopamine Transporter.
Applicazioni
Anti-Dopamine Transporter Antibody, clone mAb16 is a highly specific mouse monoclonal antibody & that targets Dopamine Transporter & has been tested in western blotting.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
Western Blotting Analysis: A representative lot from an independent laboratory detected Dopamine Transporter in rat striatal membrane tissue lysate.
Qualità
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Dopamine Transporter in 10 µg of mouse brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Dopamine Transporter in 10 µg of mouse brain tissue lysate.
Descrizione del bersaglio
~ 68 kDa observed
Stato fisico
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Stoccaggio e stabilità
Stable for 1 year at 2-8°C from date of receipt.
Risultati analitici
Control
Mouse brain tissue lysate
Mouse brain tissue lysate
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Jon D Gaffaney et al.
Neurochemistry international, 73, 16-26 (2013-11-26)
Ligand-induced changes in the conformation of extracellular loop (EL) 2 in the rat (r) dopamine transporter (DAT) were examined using limited proteolysis with endoproteinase Asp-N and detection of cleavage products by epitope-specific immunoblotting. The principle N-terminal fragment produced by Asp-N
Durairaj Ragu Varman et al.
Behavioural brain research, 408, 113267-113267 (2021-04-02)
Dopamine (DA) transporter (DAT) is dynamically regulated by several protein kinases and the Thr53 phosphorylation of DAT (pT53-DAT) is documented in heterologous cell models and in rat brain. However, the role of endogenous pT53-DAT in living animals has never been
Katrina L Paumier et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 874-883 (2014-10-01)
In addition to alleviating depression, long-term adaptive changes induced by antidepressants may regulate neural plasticity in the diseased brain, providing symptomatic and disease-modifying effects in Parkinson's disease. The present study investigated whether chronic treatment with a frequently prescribed tricyclic antidepressant
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