AB3852
Anti-Cortactin Antibody, phospho-specific (Tyr421)
Chemicon®, from rabbit
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
affinity purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Purificato mediante
affinity chromatography
Reattività contro le specie
human, rat
Produttore/marchio commerciale
Chemicon®
tecniche
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
phosphorylation (pTyr421)
Informazioni sul gene
human ... CTTN(2017)
Specificità
Recognizes Cortactin phosphorylated on tyrosine 421. Cortactin is an 80-85 kDa actin-binding protein, which consists of a variety of protein domains. The nature and function of these domains, coupled with the presence of multiple consensus sites for phosphorylation by tyrosine and serine/threonine kinases, suggests that cortactin integrates activation of specific signaling pathways with cytoskeletal reorganization.
Immunogeno
Epitope: phospho-specific (Tyr421)
Rabbit anti-Cortactin (Y421) polyclonal antibody was raised against a peptide corresponding to residues surrounding phosphorylated Y421of human cortactin.
Applicazioni
Anti-Cortactin Antibody, phospho-specific (Tyr421) detects level of Cortactin & has been published & validated for use in WB.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeleton
Western blot: 1-2 μg/mL
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Stato fisico
Affinity purified immunoglobulin. Liquid in 1mg/mL in PBS with 0.05% Bronidox.
Stoccaggio e stabilità
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months after receipt.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Hippocampal Cortactin Levels are Reduced Following Spatial Working Memory Formation, an Effect Blocked by Chronic Calpain Inhibition.
Olson, ML; Ingebretson, AE; Harmelink, KM
Brain sciences null
Nayden G Naydenov et al.
Cells, 11(9) (2022-05-15)
Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer (CAC). The altered structure of epithelial cell-cell adhesions
Jakob Knorr et al.
European journal of microbiology & immunology, 10(1), 20-27 (2020-05-05)
The gastric pathogen Helicobacter pylori colonizes approximately half of the human world population. The bacterium injects the effector protein cytotoxin associated gene A (CagA) via a type-IV secretion system into host epithelial cells, where the protein becomes phosphorylated at specific
Yu Yu et al.
Oncogene, 37(28), 3778-3789 (2018-04-13)
Cell motility and invasiveness are prerequisites for dissemination, and largely account for cancer mortality. We have identified an actionable kinase, spleen tyrosine kinase (SYK), which is keenly tightly associated with tumor progression in ovarian cancer. Here, we report that active
Alexis Bonfim-Melo et al.
Cellular microbiology, 17(12), 1797-1810 (2015-06-23)
Trypanosoma cruzi extracellular amastigotes (EAs) display unique mechanisms for cell invasion that are highly dependent on host actin filaments. Protein kinase D1 (PKD1) phosphorylates and modulates the activity of cortactin, a key regulator of actin dynamics. We evaluated the role
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