565850

Shikonin

≥98% (HPLC), solid, Pyruvate kinase inhibitor, Calbiochem^®

• Sinonimo/i: Shikonin, Pyruvate Kinase Inhibitor II
• Formula empirica (notazione di Hill): C₁₆H₁₆O₅
• Numero CAS: 517-89-5
• Peso molecolare: 288.30
• Numero MDL: MFCD00075680
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• product name: Shikonin, A naphthoquinone found in the Chinese herb Shiunko.
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: red
• Solubilità: DMSO: 10 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3; NEZONWMXZKDMKF-UHFFFAOYSA-N

Descrizione

Descrizione generale

A naphthoquinone found in the Chinese herb Lithospermum erythrorhizon. Possesses significant antibacterial, anti-inflammatory and antitumor activities. Inhibits TNF-α and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αVβ3 and inhibits endothelial cells proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line. Selectively blocks PKM2 (IC₅₀<1 µM) over PKM1 and PKL activities (IC₅₀ in the range of 10-20 µM), and inhibits cancer cell glycolysis.

A naphthoquinone found in the Chinese herb Shiunko. Possesses significant antibacterial, anti-inflammatory, and antitumor activities. Inhibits TNF-α-induced and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin α_vβ₃ and inhibits endothelial cell proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
TNF-α-induced and B-16 melanoma-induced angiogenesis

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Chen, J., et al. 2011. Oncogene30, 4297.
Li, H., et al. 1999. Phytother. Res.13, 236.
Yoon, Y., et al. 1999. Planta Med.65, 532.
Hisa, T., et al. 1998. Anticancer Res. 18, 783.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable