The stability of this inhibitor in cell culture media has not been evaluated in-house and is expected to vary from one cell culture model system to another. The required frequency of refreshing culture medium containing this inhibitor should be determined empirically for the specific model system. Published literature may be used as a guide.
551476
Q-VD-OPh, Non-O-methylated
≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem®
Sinonimo/i:
InSolution Q-VD-OPh, Non-O-methylated, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
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1 MG
CHF 289.00
5 MG
CHF 934.00
CHF 289.00
Spedizione prevista il16 maggio 2025
Scegli un formato
Cambia visualizzazione
1 MG
CHF 289.00
5 MG
CHF 934.00
About This Item
Formula empirica (notazione di Hill):
C26H25F2N3O6
Peso molecolare:
513.49
Codice UNSPSC:
12352200
NACRES:
NA.77
CHF 289.00
Spedizione prevista il16 maggio 2025
Prodotti consigliati
Nome del prodotto
Q-VD-OPh, Non-O-methylated, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases
Livello qualitativo
Saggio
≥90% (HPLC)
Stato
liquid
Produttore/marchio commerciale
Calbiochem®
Condizioni di stoccaggio
OK to freeze
desiccated (hygroscopic)
protect from light
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Descrizione generale
A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
Azioni biochim/fisiol
Cell permeable: yes
Primary Target
caspase-1
caspase-1
Product does not compete with ATP.
Reversible: no
Target IC50: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
Confezionamento
Packaged under inert gas
Attenzione
Toxicity: Irritant (B)
Sequenza
Q-Val-Asp-CH₂-OPh
Stato fisico
Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.
Ricostituzione
Following initial thaw, aliquot and freeze (-20°C).
Altre note
Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Punto d’infiammabilità (°C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificati d'analisi (COA)
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Is Q-VD-OPh, Non-O-methylated and Bcl-2 Inhibitor VI, ABT-737 – CAS 852808-04-9-Calbiochem (197333, reconstituted in DMSO) stable in cell culture media at 37C for cell-based assays?
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