5.38094

P18IN011

• Sinonimo/i: P18IN011, 1,2-Benzoxazol-3-yl-4-acetamidobenzenesulfonate, p18-Cdk6 Interaction Blocker, p18INK4C Inhibitor
• Formula empirica (notazione di Hill): C₁₅H₁₂N₂O₅S
• Numero CAS: 77408-67-4
• Peso molecolare: 332.33
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Livello qualitativo: 100
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: DMSO: 50 mg/mL
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C15H12N2O5S/c1-10(18)16-11-6-8-12(9-7-11)23(19,20)22-15-13-4-2-3-5-14(13)21-17-15/h2-9H,1H3,(H,16,18); SIXNKGXJEIVCDH-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable benzoxazolyl-acetamidobenzenesulfonate compound that directly interacts with p18 protein and blocks its activity. Specifically disrupts p18-Cdk6 complex formation with no effect on p16-Cdk6 interaction. Shown to significantly expand HSCs long-term repopulating ability by ~4.2-fold and increase the frequency with an ED₅₀ of 5.70 µM. Suggested to exert little influence through cell proliferation and apoptosis.

A cell-permeable benzoxazolyl-acetamidobenzenesulfonate compound that directly interacts with p18 protein and blocks its activity. Specifically disrupts p18-Cdk6 complex formation with no effect on p16-Cdk6 interaction. Shown to significantly expand HSCs long-term repopulating ability by ~4.2-fold and increase the frequency with an ED₅₀ of 5.70 µM. Suggested to exert little influence through cell proliferation and apoptosis.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
p18

Reversible: yes

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Gao, Y., et al. 2015. Nat. Commun.6, 6328.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 612.1 °F
• Punto d’infiammabilità (°C): 322.3 °C