529605-M

PP1 Analog

InSolution, ≥97%, ATP-competitive, inhibitor of Src-family tyrosine kinases

• Sinonimo/i: InSolution PP1 Analog
• Formula empirica (notazione di Hill): C₁₉H₁₉N₅
• Numero CAS: 221243-82-9
• Peso molecolare: 317.39
• Codice UNSPSC: 12352200

Proprietà

• Saggio: ≥97% (HPLC)
• Stato: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Temperatura di conservazione: −70°C
• InChI: 1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22); XSHQBIXMLULFEV-UHFFFAOYSA-N

Descrizione

Descrizione generale

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1.0 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC₅₀ = 1.5 nM) compared to wild-type v-Src (IC₅₀ = 1.0 µM). Also inhibits wild-type Fyn (IC₅₀ = 600 nM). A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

Attenzione

Toxicity: Irritant (B)

Stato fisico

A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.

Ricostituzione

Following initial thaw, aliquot and freeze (-70°C).

Altre note

Bishop, A.C., et al. 2000. Nature407, 395.
Bishop, A.C., et al. 1999 J. Am. Chem. Soc.121, 627.

Note legali

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Punto d’infiammabilità (°C): 87 °C - closed cup - (Dimethylsulfoxide)