P0040

PP1

≥98% (HPLC), PTK inhibitor, powder

• Sinonimo/i: 4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine
• Formula empirica (notazione di Hill): C₁₆H₁₉N₅
• Numero CAS: 172889-26-8
• Peso molecolare: 281.36
• UNSPSC Code: 12352200
• PubChem Substance ID: 329819992
• NACRES: NA.77
• MDL number: MFCD01076570
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Nome del prodotto: PP1, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• storage temp.: room temp
• SMILES string: Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
• InChI: 1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
• InChI key: ZVPDNRVYHLRXLX-UHFFFAOYSA-N

Descrizione

Application

PP1 has been used as:

• an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn
• a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth
• a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)

Biochem/physiol Actions

PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.

PP1 is a pyrazolopyrimidine compound that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding. It also inhibits protein tyrosine kinase (PTK6) and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral