490070

Nitric Oxide Synthase, Neuronal Inhibitor I

The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Sinonimo/i: Nitric Oxide Synthase, Neuronal Inhibitor I, (4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA
• Formula empirica (notazione di Hill): C₈H₂₁N₇O₂ · 3C₂HF₃O₂ · 2H₂O
• Numero CAS: 357965-99-2
• Peso molecolare: 625.40
• Numero MDL: MFCD05865227
• Codice UNSPSC: 12352303
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic); protect from light
• Colore: white to off-white
• Solubilità: water: 1 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C8H21N7O2.3C2HF3O2/c9-3-5-12-6-7(10)2-1-4-13-8(11)14-15(16)17;3*3-2(4,5)1(6)7/h7,12H,1-6,9-10H2,(H3,11,13,14);3*(H,6,7)/t7-;;;/m0.../s1; NYWNMNBIORWOSQ-QTPLPEIMSA-N

Descrizione

Descrizione generale

A cell-permeable, potent and highly selective inhibitor of neuronal nitric oxide synthase (nNOS); (K_i = 120 nM). Displays >2500-fold and 320-fold selectivity over eNOS and iNOS, respectively.

A cell-permeable, potent, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS) (K_i = 120 nM). Displays >2,500-fold and 192-fold selectivity over eNOS and iNOS, respectively.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
nNOS

Product does not compete with ATP.

Reversible: no

Target K_i: 120 nM against nNOS

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Stato fisico

Supplied as a dihydrate.

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Hah, J.M., et al. 2001. J. Med. Chem.44, 2667.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable