OK to freeze desiccated (hygroscopic) protect from light
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Descrizione generale
A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
Confezionamento
Packaged under inert gas
Attenzione
Toxicity: Irritant (B)
Stato fisico
A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Ricostituzione
Following initial thaw, aliquot and freeze (-20°C).
Altre note
Thompson, T., et al. 2004. J. Biol. Chem.279, 53015. Vassilev, L.T., et al. 2004. Science303, 844.
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Punto d’infiammabilità (°C)
87 °C - closed cup - (Dimethylsulfoxide)
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