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Documenti

440204

Sigma-Aldrich

LY 294002

InSolution, ≥98%, 10 mM, reversible and specific inhibitor of PI 3-kinase

Sinonimo/i:

InSolution LY 294002, 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV

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About This Item

Formula empirica (notazione di Hill):
C19H17NO3
Numero CAS:
154447-36-6
Peso molecolare:
307.34
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

liquid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
protect from light

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

InChI

1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
CZQHHVNHHHRRDU-UHFFFAOYSA-N

Azioni biochim/fisiol

Cell permeable: yes
Primary Target
phosphatidylinositol 3-kinase
Product competes with ATP.
Reversible: yes
Target IC50: 1.4 µM against phosphatidylinositol 3-kinase

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Irritant (B)

Stato fisico

A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.

Ricostituzione

Following initial thaw, aliquot and freeze (-20°C).

Altre note

Dittman, A., et al. 2013. ACS Chem. Biol.9, 495.
Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA95, 14066.
Cardone, M.H., et al. 1998. Science282, 1318.
Vlahos, C.J., et al. 1995. J. Immunol.154, 2413.
Yano, H., et al. 1995. Biochem. J.312, 145.
Vlahos, C.J., et al. 1994. J. Biol. Chem.269, 5241.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.


Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

188.6 °F - (refers to pure substance)

Punto d’infiammabilità (°C)

87 °C - (refers to pure substance)

Certificati d'analisi (COA)

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