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428021

Sigma-Aldrich

Latrunculin A

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem

Sinonimo/i:

Latrunculin A, Latrunculia magnifica

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Formula empirica (notazione di Hill):
C22H31NO5S
Numero CAS:
Peso molecolare:
421.55
Codice UNSPSC:
12352200
NACRES:
NA.77

product name

Latrunculin A, Latrunculia magnifica, Latrunculin A, CAS 76343-93-6, is a cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (KD = 200 nM).

Livello qualitativo

Saggio

≥95% (HPLC)

Forma fisica

solid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
protect from light

Colore

white

Solubilità

DMSO: 25 mg/mL

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

InChI

1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1
DDVBPZROPPMBLW-IZGXTMSKSA-N

Descrizione generale

A cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos.
A cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos. A 1 mM (50 µg/119 µl) solution of Latrunculin A, Latrunculia magnifica Cat. No. 428026 in DMSO is also available.

Azioni biochim/fisiol

Cell permeable: yes
Kd = 200 nM in formation of a 1:1 complex with monomeric G-actin
Primary Target
G-actin
Product does not compete with ATP.
Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Harmful (C)

Ricostituzione

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Ayscough, K.R., et al. 1997. J. Cell Biol. 137, 399.
Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
Coue, M., et al. 1987. FEBS Lett. 213, 316.
Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.
Spector, I., et al. 1983. Science 219, 493.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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