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361515

Sigma-Aldrich

Glycogen Phosphorylase Inhibitor

The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.

Sinonimo/i:

Glycogen Phosphorylase Inhibitor, 1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea

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About This Item

Formula empirica (notazione di Hill):
C17H15ClF2N4O4
Numero CAS:
648926-15-2
Peso molecolare:
412.78
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
protect from light

Colore

white

Solubilità

DMSO: 25 mg/mL

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

InChI

1S/C17H15ClF2N4O4/c1-21-16(26)22-8-3-4-14(28-2)13(5-8)23-17(27)24-15(25)9-6-11(19)12(20)7-10(9)18/h3-7H,1-2H3,(H2,21,22,26)(H2,23,24,25,27)
ROJNYKZWTOHRNU-UHFFFAOYSA-N

Descrizione generale

A cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.

Azioni biochim/fisiol

Cell permeable: yes
Primary Target
Glycogen phosphorylase
Product does not compete with ATP.
Reversible: no
Target IC50: 53 nM against glycogen phosphorylase

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Irritant (B)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Klabunde, T., et al. 2005. J. Med. Chem.48, 6178

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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CD47 deficient mice are resistant to dextran sulfate sodium (DSS)-induced experimental colitis. The underlying mechanism, however, remains incompletely understood. In this study, we characterized the role of CD47 in modulating homeostasis of gastrointestinal tract. We found that CD47 expression in
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Theranostics, 11(18), 8674-8691 (2021-09-16)
Background: Clear cell renal cell carcinoma (ccRCC) is characterized by glycogen-laden, unexplained male predominance, and frequent mutations in the Von Hippel-Lindau (VHL) gene and histone modifier genes. Besides, poor survival rates of ccRCC patients seem to be associated with up-regulation
Kasandra S Hunter et al.
Frontiers in microbiology, 12, 726465-726465 (2021-09-21)
On entering the mammalian host, schistosomes transition from a freshwater environment where resources are scarce, to an environment where there is an unlimited supply of glucose, their preferred energy substrate. Adult schistosome glycolytic activity consumes almost five times the parasite's
Nont Kosaisawe et al.
Cell metabolism, 33(3), 649-665 (2021-02-10)
Cell-to-cell heterogeneity in metabolism plays an unknown role in physiology and pharmacology. To functionally characterize cellular variability in metabolism, we treated cells with inhibitors of oxidative phosphorylation (OXPHOS) and monitored their responses with live-cell reporters for ATP, ADP/ATP, or activity

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