260920

DNA Methyltransferase Inhibitor

The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Sinonimo/i: DNA Methyltransferase Inhibitor, 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propionic acid, RG108, DNA MTase Inhibitor I
• Formula empirica (notazione di Hill): C₁₉H₁₄N₂O₄
• Numero CAS: 32675-71-1
• Peso molecolare: 334.33
• Numero MDL: MFCD00379702
• Codice UNSPSC: 12352200
• NACRES: NA.54

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: solid
• Potenza: 115 nM IC₅₀
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: yellow
• Solubilità: DMSO: 100 mg/mL; methanol: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [nH]1c2c(c(c1)CC(N3C(=O)c4c(cccc4)C3=O)C(=O)O)cccc2
• InChI: 1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25); HPTXLHAHLXOAKV-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable, specific DNA methyltransferases inhibitor (IC₅₀ = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
CPG methylase M.Sssl

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Brueckner, B., et al. 2005. Cancer Res.65, 6305.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable