23-059-M

TRAF6, active

• Sinonimo/i: TNF receptor-associated factor 6, Interleukin-1 signal transducer, RING finger protein 85
• Codice UNSPSC: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

Proprietà

• Origine biologica: human
• Livello qualitativo: 100
• Forma fisica: liquid
• Produttore/marchio commerciale: Upstate^®
• tecniche: activity assay: suitable
• N° accesso Genebanck: BC031052

Descrizione

Descrizione generale

TRAF6 is a ubiquitin ligase essential for the activation of NF-κB and MAP kinases in multiple signalling pathways including those emanating from the tumour-necrosis-factor receptor (TNFR) and interleukin-1/Toll-like receptors (IL-1R/TLR). TRAF6 also transduces signals from receptors such as CD40 and RANK and may be essential for the formation of functional osteoclasts. Studies indicate that amplification of the TRAF6 locus is a somatic and frequent event in several human cancer types and is a commonly amplified oncogene bridging RAS and NF-κB in lung cancer. Inhibition of TRAF6 in lung cancer cells has been shown to suppress NF-κB activation, anchorage-independent growth and tumour formation.

Note legali

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Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H317
• Consigli di prudenza: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classi di pericolo: Skin Sens. 1
• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable