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220551

Sigma-Aldrich

Chloramphenicol

Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

Sinonimo/i:

Chloramphenicol

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About This Item

Formula empirica (notazione di Hill):
C11H12Cl2N2O5
Numero CAS:
56-75-7
Peso molecolare:
323.13
Numero MDL:
MFCD00078159
Codice UNSPSC:
12352200

Livello qualitativo

100

Saggio

≥97% (by Assay)

Forma fisica

crystalline powder

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze

Colore

gray to off-white

Solubilità

water: 2.5 mg/mL
methanol: 35 mg/mL
ethanol: soluble

Condizioni di spedizione

ambient

Temperatura di conservazione

10-30°C

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)
WIIZWVCIJKGZOK-UHFFFAOYSA-N

Descrizione generale

Synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.
Synthetic bacteriostatic antibiotic that inhibits the translation of RNA to protein by binding to the 50S ribosomal subunit, blocking the peptidyl transferase reaction. Chloramphenicol resistance is encoded by the resistance gene cat, whose product, chloramphenicol acetyltransferase, inactivates the antibiotic via acetylation. Typically used at 30-50 µg/ml for selection of chloramphenicol-resistant Escherichia coli.

Azioni biochim/fisiol

Potency: ≥970 µg/mg
Primary Target
trasnslation of RNA

Altre note

Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1, (Ausubel, F.M., et al., Eds.) John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993. Biochem. Biophys. Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993. Virol.197, 35.
Holt, J.T. 1992. Ann. N.Y. Acad. Sci.660, 88.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, NY, p. 1.6, A.6.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Health hazardCorrosion
GHS08,GHS05

Avvertenze

Danger

Indicazioni di pericolo

H318,H351,H361fd

Classi di pericolo

Carc. 2 - Eye Dam. 1 - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

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