189404

Aurora Kinase Inhibitor II

The Aurora Kinase Inhibitor II, also referenced under CAS 331770-21-9, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinonimo/i: Aurora Kinase Inhibitor II, 4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II
• Formula empirica (notazione di Hill): C₂₃H₂₀N₄O₃
• Numero CAS: 331770-21-9
• Peso molecolare: 400.43
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥90% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: yellow
• Solubilità: DMSO: 5 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26); IMYVCWQAHSYYOO-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable anilinoquinazoline compound that acts as a potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC₅₀ = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.

A cell-permeable, potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC₅₀ = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
Aurora Kinase

Product competes with ATP.

Reversible: no

Target IC₅₀: 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Altre note

Heron, N.M., et al. 2006. Bioorg. Med. Chem. Lett.16, 1320.
Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem.5, 807.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable