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M-077

Supelco

1-Mononitroglycerin solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formula empirica (notazione di Hill):
C3H7NO5
Numero CAS:
624-43-1
Peso molecolare:
137.09
Numero CE:
200-835-2
Numero MDL:
MFCD00661062
Codice UNSPSC:
41116107
ID PubChem:
329817829
NACRES:
NA.24

Grado

certified reference material

Forma fisica

liquid

Caratteristiche

Snap-N-Spike®/Snap-N-Shoot®

Confezionamento

ampule of 1 mL

Produttore/marchio commerciale

Cerilliant®

Concentrazione

1.0 mg/mL in acetonitrile

tecniche

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

applicazioni

pharmaceutical (small molecule)

Formato

single component solution

Temperatura di conservazione

−20°C

Stringa SMILE

O[C@H](CO)CO[N+]([O-])=O

InChI

1S/C3H7NO5/c5-1-3(6)2-9-4(7)8/h3,5-6H,1-2H2
HXWLJBVVXXBZCM-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

1-Mononitroglycerin is a major plasma metabolite of the pharmaceutical vasodilator nitroglycerin. This Certified Spiking Solution® is suitable for use in chromatography or mass spectrometry-based applications in pharmaceutical research or clinical toxicology. Nitroglycerin is used to treat heart conditions such as angina and chronic heart failure.

Applicazioni


  • Growth of Arthrobacter sp. strain JBH1 on Nitroglycerin: This study highlights the novel capability of Arthrobacter sp. strain JBH1 to metabolize nitroglycerin as its sole source of carbon and nitrogen. The findings are critical for biotechnological applications aiming to biodegrade nitroglycerin residues in contaminated environments, presenting an effective bioremediation strategy for pollutants derived from pharmaceutical manufacturing processes (Husserl et al., 2010).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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M-001

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Pittogrammi

FlameExclamation mark
GHS02,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H225,H302 + H312 + H332,H319

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

35.6 °F - closed cup

Punto d’infiammabilità (°C)

2 °C - closed cup

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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C Romanin et al.
Journal of molecular and cellular cardiology, 20(5), 389-396 (1988-05-01)
Nitrovasodilators relax vascular smooth muscle by stimulating guanylate cyclase. Ignarro et al. (1981) proposed a mechanistic scheme according to which organic nitrates release nitrite in the presence of thiols. The corresponding nitrous acid would decay leading to nitric oxide, which
H Laufen et al.
British journal of clinical pharmacology, 23(3), 287-293 (1987-03-01)
The plasma kinetics and urinary excretion of glyceryl-1-nitrate (G-1-N), a metabolite of glyceryl trinitrate with antianginal potential, were investigated in 10 healthy male volunteers, after intravenous infusion and oral administration of 20 mg G-1-N. The apparent volume of G-1-N distribution
H Laufen et al.
European journal of clinical pharmacology, 31(2), 169-175 (1986-01-01)
The plasma kinetics and urinary excretion of glycerol-1-nitrate (G-1-N), a water soluble metabolite of glycerol trinitrate with anti-anginal potential, have been investigated in healthy human volunteers following oral doses of 10, 20 and 40 mg tablets and 20 mg as
M Leitold et al.
Arzneimittel-Forschung, 36(11), 1577-1582 (1986-11-01)
The antianginal and hypotensive activity and the pharmacokinetic properties of glyceryl 1-nitrate (G-1-N) were examined in the rat and in the dog. The level and duration of antianginal and hypotensive activity were the same after single or repeated oral dosage
T Zimmermann et al.
Arzneimittel-Forschung, 44(4), 474-477 (1994-04-01)
The enantiomers of glyceryl-1-nitrate, a metabolite of glyceryl trinitrate, were pharmacologically characterized in vitro and in animals. In the Langendorff heart (l) G-1-N was double as potent as (d) G-1-N with respect to the enhancement of coronary flow. The two
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