810219P
Avanti
C12-NBD Sphingomyelin
Avanti Research™ - A Croda Brand 810219P, powder
Sinonimo/i:
N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sphingosine-1-phosphocholine
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About This Item
Formula empirica (notazione di Hill):
C41H73N6O9P
Numero CAS:
Peso molecolare:
825.03
Codice UNSPSC:
12352211
NACRES:
NA.25
Prodotti consigliati
Saggio
>99% (TLC)
Forma fisica
powder
Confezionamento
pkg of 1 × 1 mg (810219P-1mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand 810219P
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Categorie correlate
Descrizione generale
C12-NBD Sphingomyelin is a fluorescent analog of biologically active molecule, sphingomyelin. Sphingomyelin is predominantly found in the animal plasma membrane. It is abundantly present as component of cell membranes in mammals, nematodes, protozoa.
Applicazioni
C12-NBD-sphingomyelin has been used as a substrate to test substrate specificity of neutral ceramidase orthologue encoded by AsahA gene.
Azioni biochim/fisiol
Sphingomyelin (SM) is produced from phosphatidylcholine and ceramide on the cell surface and in lumen of the Golgi. SM′s high packing density and affinity to sterols form a rigid barrier to the extracellular environment. SM is also involved in the formation of lipid rafts in cell membranes, which perform important functions in signal transduction and membrane trafficking.
Confezionamento
5 mL Amber Glass Screw Cap Vial (810219P-1mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Codice della classe di stoccaggio
11 - Combustible Solids
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Sawaki Tada et al.
FEMS microbiology letters, 298(2), 157-165 (2009-08-05)
Ceramide is an important molecule not only structurally but also regulationally as a modulator of various cellular events. Ceramidase (CDase) are classified into three different types (acid, alkaline, and neutral CDases). Neutral CDase could play an important role in the
Fluorescent and Luminescent Probes for Biological Activity (1999)
Characterization of a neutral ceramidase orthologue from Aspergillus oryzae
Tada S, et al.
FEMS Microbiology Letters, 298(2), 157-165 (2009)
Hyun-Seok Lee et al.
International journal of molecular sciences, 21(3) (2020-02-08)
Human epidermis is positioned at the interface with the external environment, protecting our bodies against external challenges, including air pollutants. Emerging evidence suggests that diesel particulate extract (DPE), a major component of air pollution, leads to impairment of diverse cellular
Klazien Huitema et al.
The EMBO journal, 23(1), 33-44 (2003-12-20)
Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side product. This reaction is catalysed by SM synthase, an enzyme whose biological potential can
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