QBD10273
Fmoc-N-amido-dPEG®8-acid
>95% (HPLC)
Sinonimo/i:
Fmoc-N-amido-PEG8-COOH, Fmoc-N-amido-PEG8-acid, Fmoc-NH-PEG8-acid, Fmoc-PEG-acid
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About This Item
Formula empirica (notazione di Hill):
C34H49NO12
Peso molecolare:
663.75
Numero MDL:
Codice UNSPSC:
12352106
NACRES:
NA.22
Prodotti consigliati
Saggio
>95% (HPLC)
Forma fisica
solid or viscous liquid
Impiego in reazioni chimiche
reaction type: Pegylations
Architettura del polimero
shape: linear
functionality: heterobifunctional
Condizioni di spedizione
ambient
Temperatura di conservazione
−20°C
Caratteristiche e vantaggi
Fmoc-N-amido-dPEG8-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atom dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the Fmoc-N-amido-dPEGn-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.
Note legali
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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