930652

Pomalidomide-C₂-NH₂ hydrochloride

≥95%

• Sinonimo/i: 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, E3 Ligase Ligand 17
• Formula empirica (notazione di Hill): C₁₅H₁₆N₄O₄ · xHCl
• Numero CAS: 2305369-00-8
• Peso molecolare: 316.31 (free base basis)
• UNSPSC Code: 12352101
• NACRES: NA.21
• MDL number: MFCD31730839

Proprietà

• ligand: pomalidomide
• Quality Segment: 100
• assay: ≥95%
• form: powder
• technique(s): targeted protein degradation: suitable
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCN)=CC=C3)=O)=O.Cl
• InChI: 1S/C15H16N4O4.ClH/c16-6-7-17-9-3-1-2-8-12(9)15(23)19(14(8)22)10-4-5-11(20)18-13(10)21;/h1-3,10,17H,4-7,16H2,(H,18,20,21);1H
• InChI key: DSJCOXQYDMWPEY-UHFFFAOYSA-N

Descrizione

Application

Pomalidomide-C₂-NH₂ Hydrochloride is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with carboxyl linkers due to the presence of an amine group via peptide coupling reactions. It is also active for linker attachment via reductive amination, and a basic building block for development of a protein degrader library.


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Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable