920517

6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid

• Sinonimo/i: Rigid linker for PROTAC^® development
• Formula empirica (notazione di Hill): C₁₅H₂₂N₄O₄
• Numero CAS: 1700483-37-9
• Peso molecolare: 322.36
• Codice UNSPSC: 12352106
• NACRES: NA.22

Proprietà

• Impiego in reazioni chimiche: reagent type: linker
• Livello qualitativo: 100
• Gruppo funzionale: Boc; carboxylic acid
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CC(C)(OC(N1CCCN(C2=CN=CC(C(O)=O)=N2)CC1)=O)C

Descrizione

Applicazioni

6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920525
920681

Altre note

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable