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Merck
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Documenti fondamentali

806382

Sigma-Aldrich

Poly(N-isopropylacrylamide)

carboxylic acid terminated

Sinonimo/i:

NIPAM polymer, PNIPAM, functionalized polyNIPAM

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About This Item

Formula empirica (notazione di Hill):
C4H7O2(C6H11NO)nH
Codice UNSPSC:
12162002
NACRES:
NA.23

Stato

powder

PM

average Mw 10,000

Ind. polidispersione

<1.3

Temperatura di conservazione

2-8°C

Applicazioni

PolyNIPAM is a stimuli-responsive polymer. The low PDI means that the distribution of chain lengths is narrow which will typically lead to better reproducibility. This polymer for development of thermosensitive coated micro/nano materials[1] including thermoresponsive polymeric drug delivery systems.[2][3] The carboxylic acid functional group can be used to conjugate a variety of biomolecules to the polymer chain.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Ravin Narain et al.
Langmuir : the ACS journal of surfaces and colloids, 23(11), 6299-6304 (2007-04-25)
We describe here the synthesis of 10 nm, monodisperse, iron oxide nanoparticles that we have coated with temperature-sensitive, biotinylated p(NIPAAm) (b-PNIPAAm). The PNIPAAm was prepared by the reversible addition fragmentation chain transfer polymerization (RAFT), and one end was biotinylated with
W L Hinrichs et al.
Journal of controlled release : official journal of the Controlled Release Society, 60(2-3), 249-259 (1999-07-30)
Copolymers of 2-(dimethylamino) ethyl methacrylate (DMAEMA) and N-isopropylacryl amide (NIPAAm) of various monomer ratios and molecular weights were evaluated as carrier systems for DNA delivery. All copolymers, even with a low DMAEMA content of 15 mol%, were able to bind
J E Chung et al.
Journal of controlled release : official journal of the Controlled Release Society, 62(1-2), 115-127 (1999-10-16)
To achieve a combination of spatial specificity in a passive manner with a stimuli-responsive targeting mechanism, a temperature-responsive polymeric micelle is prepared using block copolymers of (poly(N-isopropylacrylamide-b-butylmethacrylate) (PIPAAm-PBMA)). The micelle inner core formed by self-aggregates of PBMA segments successfully loaded

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