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440744

Sigma-Aldrich

Polycaprolactone

average Mn 80,000

Sinonimo/i:

2-Oxepanone homopolymer, 6-Caprolactone polymer

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About This Item

Formula condensata:
(C6H10O2)n
Codice UNSPSC:
12162002
NACRES:
NA.23

Forma fisica

pellets (~3 mm)

PM

average Mn 80,000

Impurezze

<0.5% water

Punto di fusione

60 °C (lit.)

Densità

1.145 g/mL at 25 °C

Mw/Mn

<2

applicazioni

3D bioprinting
advanced drug delivery

Stringa SMILE

C1CCC(=O)OCC1 (Canonical-SMILES)

InChI

1S/C6H10O2/c7-6-4-2-1-3-5-8-6/h1-5H2
PAPBSGBWRJIAAV-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

Polycaprolactone (PCL) is a semi crystalline hydrophobic biodegradable polyester which finds major applications as a drug delivery agent because of its cost efficiency, high toughness and biocompatibility. PCL possesses some unique properties such as:
  • It degrades slower than other biodegradable polyesters in physiological condition, this property can be exploited in the controlled release of drugs in target tissues over a period of time.
  • Its poor surface wetting and interaction with biological fluids on account of its hydrophobicity leads to poor cell adhesion and proliferation, hence it is blended with other synthetic /natural polymers.

Applicazioni

  • PCL loaded with antibiotics may be used to treat infections of the respiratory tract, like tuberculosis.
  • Investigations were carried out based upon phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) for different ratio of chitosan/ polycaprolactone (PCL) blends.
  • PCL/biomedical ceramic materials have been studied for possible osteo tissue regeneration.
  • Action of PCL/graded insulin/beta-5 glycerophosphate concentrations on osteochondral tissue formation through adipose-derived stromal cell differentiation.
  • Other general uses include:extrusion aid, die lubricant, mold release, pigment and filler dispersion aid and polyester segments in urethanes and block polyesters.

Caratteristiche e vantaggi

Biodegradable polymer
Non-toxic, biodegradable in soil, broad miscibility, mechanical compatibility with many polymers and good adhesion to a broad spectrum of substrates.

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Resomer&#174; C 209, Poly(caprolactone) ester terminated

Sigma-Aldrich

769762

Resomer® C 209, Poly(caprolactone)

Hung-Jen Shao et al.
Journal of biomedical materials research. Part A, 100(12), 3344-3352 (2012-06-27)
The phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) on different ratio of chitosan/polycaprolactone (PCL) blends were investigated in this study. The results showed that hBMSCs existed different morphology on chitosan/PCL blends due to the different adhesion characteristic of
Cevat Erisken et al.
Tissue engineering. Part A, 17(9-10), 1239-1252 (2010-12-30)
The ability to fabricate tissue engineering scaffolds containing systematic gradients in the distributions of stimulators provides additional means for the mimicking of the important gradients observed in native tissues. Here the concentration distributions of two bioactive agents were varied concomitantly
Muhammad Shafiq et al.
Arteriosclerosis, thrombosis, and vascular biology, 38(7), e117-e134 (2018-06-02)
The objective of this study was to develop small-diameter vascular grafts capable of eluting SDF (stromal cell-derived factor)-1α-derived peptide and SP (substance P) for in situ vascular regeneration. Polycaprolactone (PCL)/collagen grafts containing SP or SDF-1α-derived peptide were fabricated by electrospinning.
Kalaipriya Madhaiyan et al.
International journal of pharmaceutics, 444(1-2), 70-76 (2013-02-02)
Biocompatible PCL polymer nanofiber mediated sustained release of hydrophilic drug and applicability as transdermal delivery system is attempted. This new attempt to investigate water soluble vitamin delivery with hydrophobic polymer nanofiber sustained the release of the vitamin and the method
Jixin Xue et al.
Biomaterials, 34(11), 2624-2631 (2013-01-29)
Tissue engineering approach continuously requires for emerging strategies to improve the efficacy in repairing and regeneration of tissue defects. Previously, we developed a sandwich model strategy for cartilage engineering, using the combination of acellular cartilage sheets (ACSs) and chondrocytes. However
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