389145

(2-idrossipropil)-β-ciclodestrina

average M_w ~1,540

• Sinonimo/i: (2-Hydroxypropyl)-beta-cyclodextrin
• Numero CAS: 128446-35-5
• Numero CE: 420-920-1
• Codice UNSPSC: 12352201
• ID PubChem: 24864264
• NACRES: NA.22

Proprietà

• Forma fisica: powder
• Attività ottica: [α]23/D +125°, c = 1 in H₂O
• PM: average M_w ~1,540
• Grado di funzionalizzazione: 1.0 molar substitution dextrin
• Stringa SMILE: CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O
• InChI: 1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1; ODLHGICHYURWBS-RYJYQAAZSA-N

Descrizione

Descrizione generale

2-Hydroxypropyl-β-cyclodextrin is a cyclic oligosaccharide and used as a pharmaceutical excipient to improve the stability and bioavailability of drugs.

(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, is mainly used as a formulation vehicle to increase the dissolution of drugs in water for the successful delivery of medicinal agents to biological systems. It is commonly utilized as a substitute for α-, β- and γ-cyclodextrins.

Applicazioni

(2-Hydroxypropyl)-β-cyclodextrin may be used:

• As an analytical standard for the determination of the analyte in pharmaceutical formulations as well as nanoparticle formulations by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC), respectively.
• To study the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase HPLC technique.
• As a mobile phase additive for the effective separation of β-carbolines by HPLC.
• In cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) for the determination of sertraline hydrochloride and the synthesis-related products.
• As a chiral selector to resolve pantothenic acid by capillary electrophoresis.

La solubilità dei farmaci lipofili aumenta linearmente con la concentrazione di idrossipropil-β-ciclodestrina (HBC) in soluzione acquosa a causa del complesso che si forma fra HBC e il farmaco. Questo complesso di tipo ospite/ospitante si forma tra il farmaco e la cavità non polare della HBC aumentando la solubilità. È possibile liofilizzare le soluzioni per produrre polveri facilmente solubili. Non tossico nel coniglio e nel topo.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)