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207713

Sigma-Aldrich

1,3-Di-o-tolylguanidine

99%

Sinonimo/i:

DTG

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About This Item

Formula condensata:
(CH3C6H4NH)2C(=NH)
Numero CAS:
97-39-2
Peso molecolare:
239.32
Numero CE:
202-577-6
Numero MDL:
MFCD00008513
Codice UNSPSC:
12352100
ID PubChem:
24852467
NACRES:
NA.22
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Saggio

99%

Stato

solid

Punto di fusione

176-178 °C (lit.)

Solubilità

water: soluble 70 mg/mL at 20 °C

Gruppo funzionale

amine

Stringa SMILE

Cc1ccccc1NC(=N)Nc2ccccc2C

InChI

1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
OPNUROKCUBTKLF-UHFFFAOYSA-N

Informazioni sul gene

human ... EBP(10682)

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Categorie correlate

Descrizione generale

1,3-Di-o-tolylguanidine is a selective σ-receptor agonist[1]. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice[2].

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
MKCW7506
MKCV7802
MKCW1599
MKCW1600
MKCW8211

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F P Monnet et al.
The Journal of pharmacology and experimental therapeutics, 307(2), 705-712 (2003-09-17)
Intracellular calcium concentration ([Ca2+]i) plays a major role in neuronal excitability, especially that triggered by the N-methyl-d-aspartate (NMDA)-sensitive glutamatergic receptor. We have previously shown that sigma1 receptor agonists potentiate NMDA receptor-mediated neuronal activity in the hippocampus and recruit Ca2+-dependent second
Thibault Mesplède et al.
AIDS (London, England), 29(6), 659-665 (2015-04-08)
In treatment-naive HIV-positive individuals, the integrase strand-transfer inhibitor dolutegravir (DTG) has not been associated with emergent drug-resistance mutations, neither against this drug nor against other antiretroviral drugs that were used in combination with it. This is in contrast to all
J Maj et al.
Polish journal of pharmacology, 48(4), 379-395 (1996-07-01)
1,3-Di-o-tolylguanidine (DTG), opipramol (OPI) and sertraline (SER), sigma site ligands, were studied in Wistar rats and Albino Swiss mice, mainly with regard to their interaction with dopamine drugs. DTG and SER (at the highest doses only) decreased the spontaneous locomotor
Takato Hiranita et al.
Behavioural pharmacology, 22(5-6), 525-530 (2011-08-03)
Previous studies demonstrated the effectiveness of selective σ-receptor (σR) agonists [1,3-di-o-tolylguanidine (DTG), PRE-084] as reinforcers in rats trained to self-administer cocaine. Similar to cocaine, these drugs increased nucleus accumbens shell dopamine levels, and effects of DTG, but not PRE-084, on
Zur Mira Azizah Nor Haiza Lah et al.
Journal of pharmaceutical and biomedical analysis, 174, 608-617 (2019-07-03)
A facile electrochemical sandwich immunosensor for the detection of a breast cancer biomarker, the human epidermal growth factor receptor 2 (HER2), was designed, using lead sulfide quantum dots-conjugated secondary HER2 antibody (Ab2-PbS QDs) as a label. Using Ab2-PbS QDs in
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Questions

1–3 of 3 Questions  

  1. What is the nature of the biological activity of Product 207713, 1,3-di-o-tolylguanidine?

    1 answer

    1. 1,3-Di-o-tolylguanidine is known to be a selective ligand for the sigma site in the mammalian central nervous system. Behavioral changes, such as hypothermia, reduced pain behavior, circling behavior, and decreased locomotor activity in mice and/or rats were observed after intraperitoneal, subcutaneous, intravenous and/or intranigral injection.

      Helpful?

  2. What is the solubility of Product 207713, 1,3-di-o-tolylguanidine?

    1 answer

    1. 1,3-Di-o-tolylguanidine is soluble in water at 70 micrograms per mL at ambient temperature.

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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