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Documenti fondamentali

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180246

Sigma-Aldrich

2-Naphthoic acid

98%

Sinonimo/i:

2-Naphthalenecarboxylic acid

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About This Item

Formula condensata:
C10H7CO2H
Numero CAS:
93-09-4
Peso molecolare:
172.18
Beilstein:
972039
Numero CE:
202-217-8
Numero MDL:
MFCD00004101
Codice UNSPSC:
12352100
ID PubChem:
24850857
NACRES:
NA.22

Livello qualitativo

100

Saggio

98%

Stato

powder

Punto di fusione

185-187 °C (lit.)

Solubilità

alcohol: soluble
diethyl ether: soluble
hot water: slightly soluble

Gruppo funzionale

carboxylic acid

Stringa SMILE

OC(=O)c1ccc2ccccc2c1

InChI

1S/C11H8O2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H,12,13)
UOBYKYZJUGYBDK-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

2-Naphthoic acid (NPA) is a noncompetitive N-methyl-D-aspartate (NMDA) receptor inhibitor. The fluorescence spectra and electronic absorption of 2-naphthoic acid was studied.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
STBJ9524
STBJ9508
STBH2307
STBG1725V
S15811V

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Sigma-Aldrich

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Sigma-Aldrich

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2-Hydroxy-1-naphthoic acid 98%

Sigma-Aldrich

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Naptalam PESTANAL®, analytical standard

Supelco

33371

Naptalam

Han Yu et al.
Molecular pharmacology, 84(4), 541-550 (2013-07-23)
N-Methyl-D-aspartate (NMDA) receptors mediate excitatory synaptic transmission in the central nervous system and play important roles in synaptic development and plasticity, but also mediate glutamate neurotoxicity. Recently, 2-naphthoic acid (NPA) and its derivatives have been identified as allosteric, noncompetitive NMDA
D P McNamara et al.
Journal of pharmaceutical sciences, 75(9), 858-868 (1986-09-01)
A mass transfer model was developed to describe the dissolution and reaction of acidic and basic compounds from a rotating disk in unbuffered water. Dissolution of two carboxylic acids, 2-naphthoic acid (1) and naproxen [(+)-6-methoxy-alpha-methyl-2-naphthaleneacetic acid, 2], and the free
K L Yu et al.
Journal of medicinal chemistry, 39(12), 2411-2421 (1996-06-07)
In search for retinoic acid receptor (RAR) selective ligands, a series of 6-substituted 2-naphthoic acid retinoids were synthesized and evaluated in vitro in a transactivation assay and a competition binding assay for all RARs. These derivatives, in general, showed RAR
An electronic spectral study of the influence of thermal and electronic processes on the determination of the excited singlet-state dissociation constants of 1-and 2-naphthoic acid.
Kovi PJ and Schulman SG.
Analytica Chimica Acta, 63(1), 39-52 (1973)
Blaise Mathias Costa et al.
Neuropharmacology, 62(4), 1730-1736 (2011-12-14)
Over-activation of N-methyl-d-aspartate (NMDA) receptors is critically involved in many neurological conditions, thus there has been considerable interest in developing NMDA receptor antagonists. We have recently identified a series of naphthoic and phenanthroic acid compounds that allosterically modulate NMDA receptors
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